장기 중선량률 감마선 피폭에 의한 마우스의 생존율 및생물학적 영향 평가 (Survival Rate and Biological Effect of Chronic Medium-Dose-Rate Gamma Radiation Exposed to Mice)

서지정보

· 발행기관 : (사)한국방사선산업학회
· 수록지 정보 : 방사선산업학회지 / 7권 / 2호 / 155 ~ 159페이지
· 저자명 : 김재경, 진영배, 오수미, 이윤종, 성낙윤, 송범석, 박종흠, 변의백, 이주운, 김재훈

초록

Late effects of chronic exposure to gamma radiation are potential hazards to workerin radiation facilities as well as to the general public. Recently, chronic gamma radiation exposureeffects have become a serious concern. Using a total of 60 mice, we studied the biological effects ofmedium-dose chronic exposure to gamma radiation. Sixty female 6-week-old specific pathogenfree Balb/c mice were randomly divided into six groups (five groups irradiated and one non-irradiatedcontrol group). Irradiation was carried out for 7 days using gamma rays at dose rates of119.65, 238.10, 357.14, 476.19 and 595.24 mGy h-1 with total doses 20, 40, 60, 80 and 100 Gy. Afterirradiation, we determined survival rate of gamma radiation exposed mice during 1 week and476.19 and 595.24 mGy h-1 exposed group mice showed less 10% of survival rate. Otherwise,119.65, 238.10 and 357.14 mGy h-1 exposed group mice were survived each 100%, 80% and 70%.
Half of survived mice after 1 week are immediately sacrifice and counted body and spleen weights.
Compared with control non-irradiated group, total body weights and spleen weights isolated from119.65, 238.10 and 357.14 irradiated group mice showed significant decreased. However, no significantalteration was observed between 119.65, 238.10 and 357.14 mGy h-1 irradiated group.
Overall, our results show for the first time that medium-dose chronic gamma radiation has thepotential to stimulation of biological effects.

영어초록

Late effects of chronic exposure to gamma radiation are potential hazards to workerin radiation facilities as well as to the general public. Recently, chronic gamma radiation exposureeffects have become a serious concern. Using a total of 60 mice, we studied the biological effects ofmedium-dose chronic exposure to gamma radiation. Sixty female 6-week-old specific pathogenfree Balb/c mice were randomly divided into six groups (five groups irradiated and one non-irradiatedcontrol group). Irradiation was carried out for 7 days using gamma rays at dose rates of119.65, 238.10, 357.14, 476.19 and 595.24 mGy h-1 with total doses 20, 40, 60, 80 and 100 Gy. Afterirradiation, we determined survival rate of gamma radiation exposed mice during 1 week and476.19 and 595.24 mGy h-1 exposed group mice showed less 10% of survival rate. Otherwise,119.65, 238.10 and 357.14 mGy h-1 exposed group mice were survived each 100%, 80% and 70%.
Half of survived mice after 1 week are immediately sacrifice and counted body and spleen weights.
Compared with control non-irradiated group, total body weights and spleen weights isolated from119.65, 238.10 and 357.14 irradiated group mice showed significant decreased. However, no significantalteration was observed between 119.65, 238.10 and 357.14 mGy h-1 irradiated group.
Overall, our results show for the first time that medium-dose chronic gamma radiation has thepotential to stimulation of biological effects.

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