Itraconazole로 치료된 원발성 피부 효모균증 1예 (A Case of Primary Cutaneous Cryptococcosis Treated with Itraconazole)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 11권 / 1호 / 113 ~ 120페이지
· 저자명 : 김현철, 김영진, 채영수, 서기석, 김상태

초록

-Abstract- Cryptococcosis is a systemic disease caused by yeast-like fungus Cryptococcus neoformans. It usually involves brain and meninges. However, the primary cutaneous cryptococcosis involving skin alone is rare. Amphotericin B and fluorocytosine have both been reported to be effective as the mainstay of treatment. However, the use of amphotericin B and fluorocytosine should be restricted owing to their adverse effect. We report a case of primary cutaneous cryptococcosis in a 12-ear-old male, who had erythematous hard nodules with ulcers and crusts on the face and neck for five months. Physical examination and laboratory findings other than skin lesion were within normal limits. Histopathologic features of the nodule showed many spores with thick capsules and chronic inflammatory infiltrates composed of lymphocytes, histiocytes and giant cells. A tissue culture of the lesion on Sabouraud’s media without cycloheximide at 37℃ showed moist, smooth, mucoid cream colored colonies 3 days later and revealed encapsulated yeast cells in India ink preparations. Our patient was successfully treated with oral itraconazole without side effect.

영어초록

-Abstract- Cryptococcosis is a systemic disease caused by yeast-like fungus Cryptococcus neoformans. It usually involves brain and meninges. However, the primary cutaneous cryptococcosis involving skin alone is rare. Amphotericin B and fluorocytosine have both been reported to be effective as the mainstay of treatment. However, the use of amphotericin B and fluorocytosine should be restricted owing to their adverse effect. We report a case of primary cutaneous cryptococcosis in a 12-ear-old male, who had erythematous hard nodules with ulcers and crusts on the face and neck for five months. Physical examination and laboratory findings other than skin lesion were within normal limits. Histopathologic features of the nodule showed many spores with thick capsules and chronic inflammatory infiltrates composed of lymphocytes, histiocytes and giant cells. A tissue culture of the lesion on Sabouraud’s media without cycloheximide at 37℃ showed moist, smooth, mucoid cream colored colonies 3 days later and revealed encapsulated yeast cells in India ink preparations. Our patient was successfully treated with oral itraconazole without side effect.

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