프로톤펌프억제제와 클로피도그렐(clopidogrel) 병용투여는 안전한가? (Proton Pump Inhibitors with Clopidogrel: Is There Benefit or Harm?)

서지정보

· 발행기관 : 대한내과학회
· 수록지 정보 : 대한내과학회지 / 80권 / 4호 / 405 ~ 407페이지
· 저자명 : 전성우

초록

The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors (PPIs) are often recommended for prophylaxis of gastrointestinal bleeding. Recent studies have shown that the cardiovascular harmful effects of the combination therapy with these two drugs cause serious results in patients with acute coronary syndrome. However, the data on this subject, especially on the clinical outcomes, are conflicting. Based on the available data, the decision to prescribe a PPI to a patient on clopidogrel should be done after evaluation of the cardiovascular risk and the gastrointestinal benefit. Further prospective randomized trials are needed to jump to the conclusions. (Korean J Med 2011;80:405-407)

영어초록

The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors (PPIs) are often recommended for prophylaxis of gastrointestinal bleeding. Recent studies have shown that the cardiovascular harmful effects of the combination therapy with these two drugs cause serious results in patients with acute coronary syndrome. However, the data on this subject, especially on the clinical outcomes, are conflicting. Based on the available data, the decision to prescribe a PPI to a patient on clopidogrel should be done after evaluation of the cardiovascular risk and the gastrointestinal benefit. Further prospective randomized trials are needed to jump to the conclusions. (Korean J Med 2011;80:405-407)

참고자료

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