HT-29 대장암 세포에서 5-fluorouracil과 Lactic Acid Bacteria를 복합 처리하였을 때 나타나는 Apoptosis 시너지 효과에 관한 연구 (Combination of 5-fluorouracil and Lactic Acid Bacteria Induces Apoptosis Synergistically in HT-29 Colon Cancer Cells)

서지정보

· 발행기관 : 대한암예방학회
· 수록지 정보 : 대한암예방학회지 / 14권 / 2호 / 111 ~ 117페이지
· 저자명 : 김혜민, 김홍익, 박옥진, 김영민, 박송이, 이윤경, 김윤이

초록

5-fluorouracil (5-FU) is one of the widely used chemo-therapeutic drugs targeting various cancer cells.
A successful chemotreatment requires overcoming several obstacles including intrinsically drugchemoreisitant
cancer malignancy. In the present study, HT-29 colon cancer cells were markedly sensitized
to apoptosis by both 5-FU and lactic acid bacteria (LAB), compared to the LAB treatment alone. The
precise mechanism by which LAB may inhibit the growth of colon cancer are presently unknown. It
has been reported that treatment of HT-29 colon cancer cells with combined 5-FU and LAB markedly
reduced tumor cell viability, in contrast to the results for LAB alone. Consequently, combination of 5-FU
and LAB increased significantly activation of AMP-activated protein kinase (AMPK) that has been
implicated in cancer development and control. These results suggest that the combination of 5-FU and
LAB exert a novel chemotherapeutic effect in colon cancer cells.

영어초록

5-fluorouracil (5-FU) is one of the widely used chemo-therapeutic drugs targeting various cancer cells.
A successful chemotreatment requires overcoming several obstacles including intrinsically drugchemoreisitant
cancer malignancy. In the present study, HT-29 colon cancer cells were markedly sensitized
to apoptosis by both 5-FU and lactic acid bacteria (LAB), compared to the LAB treatment alone. The
precise mechanism by which LAB may inhibit the growth of colon cancer are presently unknown. It
has been reported that treatment of HT-29 colon cancer cells with combined 5-FU and LAB markedly
reduced tumor cell viability, in contrast to the results for LAB alone. Consequently, combination of 5-FU
and LAB increased significantly activation of AMP-activated protein kinase (AMPK) that has been
implicated in cancer development and control. These results suggest that the combination of 5-FU and
LAB exert a novel chemotherapeutic effect in colon cancer cells.

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