삼정환의 랫드를 이용한 단회 경구투여 독성시험 (Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats)

서지정보

· 발행기관 : 한방비만학회
· 수록지 정보 : 한방비만학회지 / 17권 / 2호 / 96 ~ 100페이지
· 저자명 : 김민지, 김호준, 이명종

초록

Objectives: Samjung-hwan (SJH) is a Korean herbal formula that has been used for antilipidemic,antioxidant, and antidepressant effects. As a part of safety evaluation, single oral dose toxicitystudy of modified SJH in Sprague-Dawley (SD) rats was carried out.
Methods: Modified SJH extract was administered orally in male and female SD rats at dose of5,000 mg/kg. After single oral administration of modified SJH, we monitored the changes ofmortalities, clinical signs, and body weight daily for 14 days. Gross necropsy findings were alsoevaluated at the end of the experiment.
Results: Modified SJH extract did not induce any toxic signs in the changes of mortalities, clinicalsigns, and body weight. There were also observed no gross necropsy findings in rats.
Conclusions: As results, the approximate lethal dose of modified SJH extract in SD rats wasconsidered to be over 5,000 mg/kg. This suggests that modified SJH is safe herbal formula forthe treatment with

영어초록

Objectives: Samjung-hwan (SJH) is a Korean herbal formula that has been used for antilipidemic,antioxidant, and antidepressant effects. As a part of safety evaluation, single oral dose toxicitystudy of modified SJH in Sprague-Dawley (SD) rats was carried out.
Methods: Modified SJH extract was administered orally in male and female SD rats at dose of5,000 mg/kg. After single oral administration of modified SJH, we monitored the changes ofmortalities, clinical signs, and body weight daily for 14 days. Gross necropsy findings were alsoevaluated at the end of the experiment.
Results: Modified SJH extract did not induce any toxic signs in the changes of mortalities, clinicalsigns, and body weight. There were also observed no gross necropsy findings in rats.
Conclusions: As results, the approximate lethal dose of modified SJH extract in SD rats wasconsidered to be over 5,000 mg/kg. This suggests that modified SJH is safe herbal formula forthe treatment with

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