만성 비부비동염에서 알레르기비염과 말초 호산구증다증의 의미 (Significance of Peripheral Eosinophilia and Allergic Rhinitis in Chronic Rhinosinusitis)

서지정보

· 발행기관 : 대한이비인후과학회
· 수록지 정보 : 대한이비인후-두경부외과학회지 / 51권 / 3호 / 234 ~ 239페이지
· 저자명 : 심주섭, 김성완, 이건희, 조중생

초록

Chronic rhinosinusitis (CRS) frequently coexists with allergic rhinitis (AR) and nasal polyp. The
eosinophil is known to play a pivotal role in allergic reaction and chronic inflammation of respiratory epithelium in paranasal
sinus. Therefore, we evaluated the peripheral eosinophilia (PE) in patients with CRS and then investigated its relationship with
the AR. We also investigated the correlation of the prevalence of nasal polyp with the incidence of nasal polyp and the severity
of PNS CT scoring. Subjects and Method：One hundred and three CRS patients who had persisting symptoms more than 3
months and were refractory to medical management were enrolled. Thirty-six patients with AR only were selected on the basis
of allergy rhinitis workup and PNS CT. PE was defined as eosinophil count of more than 4% of the peripheral differential blood
count. The scoring system of PNS CT imaging was adopted from Ikeda, et al. Results：CRS with AR had the higher prevalence
of PE and nasal polyp (p=0.005 and p=0.046, respectively) than non-AR. CRS with AR had the higher prevalence rate of PE
than AR (p=0.001). PE was not related with the prevalence of nasal polyp in the presence of CRS with AR. Peripheral
eosinophil partition rate also did not correlate with severity of PNS CT score, irrespective of AR. There was no statistical difference
in PNS CT score between AR group and non-AR group, either. Conclusion：CRS with AR may be associated with nasal
polyp and PE but PE itself had no relationship with the disease severity on PNS CT and prevalence of nasal polyp in the presence
of CRS. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:234-9)

영어초록

Chronic rhinosinusitis (CRS) frequently coexists with allergic rhinitis (AR) and nasal polyp. The
eosinophil is known to play a pivotal role in allergic reaction and chronic inflammation of respiratory epithelium in paranasal
sinus. Therefore, we evaluated the peripheral eosinophilia (PE) in patients with CRS and then investigated its relationship with
the AR. We also investigated the correlation of the prevalence of nasal polyp with the incidence of nasal polyp and the severity
of PNS CT scoring. Subjects and Method：One hundred and three CRS patients who had persisting symptoms more than 3
months and were refractory to medical management were enrolled. Thirty-six patients with AR only were selected on the basis
of allergy rhinitis workup and PNS CT. PE was defined as eosinophil count of more than 4% of the peripheral differential blood
count. The scoring system of PNS CT imaging was adopted from Ikeda, et al. Results：CRS with AR had the higher prevalence
of PE and nasal polyp (p=0.005 and p=0.046, respectively) than non-AR. CRS with AR had the higher prevalence rate of PE
than AR (p=0.001). PE was not related with the prevalence of nasal polyp in the presence of CRS with AR. Peripheral
eosinophil partition rate also did not correlate with severity of PNS CT score, irrespective of AR. There was no statistical difference
in PNS CT score between AR group and non-AR group, either. Conclusion：CRS with AR may be associated with nasal
polyp and PE but PE itself had no relationship with the disease severity on PNS CT and prevalence of nasal polyp in the presence
of CRS. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:234-9)

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