ANTI-MÜLLERIAN HORMONE, FOLLICLE-STIMULATING HORMONE, ANTRAL FOLLICLE COUNT, AND CLINICAL FINDINGS AS PREDICTIVE MARKERS OF MENOPAUSE IN LATE REPRODUCTIVE-AGED WOMEN

서지정보

· 발행기관 : 대한산부인과학회
· 수록지 정보 : Obstetrics & Gynecology Science / 55권 / 2호 / 89 ~ 97페이지
· 저자명 : 김선미, 김석현, 이정렬, 지병철, 서창석, 이중엽, 김기철, 황도영, 김정구, 문신용

초록

Objective To assess the effi ciency of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC),endometrial thickness (EMT), and clinical fi ndings as predictive markers of menopause in late reproductive-aged Korean women.
Methods A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2.
Results Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed signifi cantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were signifi cantly associated with the occurrence of menopause.
Conclusion This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.

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