돌외 에탄올 추출물 엑스의 전기쇼크 스트레스 저항력 개선작용 (Ameliorating Effects of the Ethanol Extracts from Gynostemma pentaphyllum on Electric Footshock Stress)

서지정보

· 발행기관 : 한국생약학회
· 수록지 정보 : 생약학회지 / 39권 / 4호 / 341 ~ 346페이지
· 저자명 : 최현숙, 임선아, 박미숙, 황방연, 이종길, 김승환, 임성실, 이명구

초록

The effects of the ethanol extracts from Gynostemma pentaphyllum (GP extracts) on body weights, grip strengths,
endurances and catecholamine levels after electric footshock (EF) stress in mice and rats were investigated. The animals were
treated with GP extracts (50 mg/kg/day, p.o.) for 21 days before exposure to EF (duration and interval 10 sec for 3 min, 2 mA)
once a day. The increases in body weights were delayed by 13.1% of the control levels by EF-induced stress in mice, which
were recovered to 24.1% of the control levels in GP extract-treated groups. The grip strengths were significantly decreased by
EF stress in mice and the EF-stressed groups treated with GP extracts increased grip strengths to 115.2% compared to control
levels. The endurance times by forced swimming, which reduced significantly by EF stress, were also maintained similar to
control levels by GP extracts in rats. In addition, the levels of norepinephrine and epinephrine in serum and brain, and dopamine
in brain were significantly increased to 17.5-95.0% of the control levels after exposure of EF stress in mice. However, EF stressinduced
increases in norepinephrine and epinephrine in serum were reduced to 17.1-17.3% of the control levels by treatments
of GP extracts, and those in dopamine, norepinephrine and epinephrine in brain were also reduced to 5.0-19.5%. These results
suggest that GP extracts showed the protective effects on EF stress-induced physiological functions and can be developed as
the promising anti-stress agents.

영어초록

The effects of the ethanol extracts from Gynostemma pentaphyllum (GP extracts) on body weights, grip strengths,
endurances and catecholamine levels after electric footshock (EF) stress in mice and rats were investigated. The animals were
treated with GP extracts (50 mg/kg/day, p.o.) for 21 days before exposure to EF (duration and interval 10 sec for 3 min, 2 mA)
once a day. The increases in body weights were delayed by 13.1% of the control levels by EF-induced stress in mice, which
were recovered to 24.1% of the control levels in GP extract-treated groups. The grip strengths were significantly decreased by
EF stress in mice and the EF-stressed groups treated with GP extracts increased grip strengths to 115.2% compared to control
levels. The endurance times by forced swimming, which reduced significantly by EF stress, were also maintained similar to
control levels by GP extracts in rats. In addition, the levels of norepinephrine and epinephrine in serum and brain, and dopamine
in brain were significantly increased to 17.5-95.0% of the control levels after exposure of EF stress in mice. However, EF stressinduced
increases in norepinephrine and epinephrine in serum were reduced to 17.1-17.3% of the control levels by treatments
of GP extracts, and those in dopamine, norepinephrine and epinephrine in brain were also reduced to 5.0-19.5%. These results
suggest that GP extracts showed the protective effects on EF stress-induced physiological functions and can be developed as
the promising anti-stress agents.

참고자료

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