Choline Acetyltransferase 유전자 다형성이 경도인지손상 발현에 미치는 영향 (The Impact of Choline Acetyltransferase Polymorphism on the Expression of Mild Cognitive Impairment)

서지정보

· 발행기관 : 대한생물정신의학회
· 수록지 정보 : 생물정신의학 / 17권 / 4호 / 218 ~ 225페이지
· 저자명 : 이정재, 박준혁, 이석범, 허윤석, 김태희, 윤종철, 주진형, 이동영, 박경운, 김기웅

초록

objectives：The potential association between choline acetyltransferase(CHAT) polymorphism and the risk of mild cognitive impairment(MCI) has not been investigated in Korea. We examined the main effect of CHAT polymorphism and its interaction with apolipoprotein E(APOE) polymorphism in the development of MCI in elderly Korean sample.
Methods：We analyzed CHAT 2384G > A polymorphism and APOE polymorphism among 149 MCI subjects with MCI and 298 normal controls. We tested the association between MCI and CHAT A allele status using a logistic regression model. In addition, we employed generalized multifactor dimensionality reduction(GMDR) to investigate the interaction between CHAT and APOE with regard to the risk of MCI.Results：The CHAT A allele was associated with AD risk(OR = 1.59, 95% CI = 1.02-2.48, p = 0.042). No sig-nificant gene-gene interaction between CHAT and APOE was found in GMDR method(testing balanced accuracy = 0.540, p = 0.055).
Conclusion：The CHAT A allele was associated with MCI risk in the Korean elderly. Its interaction with the APOE ε4 allele was not significant with regard to the development of MCI.

영어초록

objectives：The potential association between choline acetyltransferase(CHAT) polymorphism and the risk of mild cognitive impairment(MCI) has not been investigated in Korea. We examined the main effect of CHAT polymorphism and its interaction with apolipoprotein E(APOE) polymorphism in the development of MCI in elderly Korean sample.
Methods：We analyzed CHAT 2384G > A polymorphism and APOE polymorphism among 149 MCI subjects with MCI and 298 normal controls. We tested the association between MCI and CHAT A allele status using a logistic regression model. In addition, we employed generalized multifactor dimensionality reduction(GMDR) to investigate the interaction between CHAT and APOE with regard to the risk of MCI.Results：The CHAT A allele was associated with AD risk(OR = 1.59, 95% CI = 1.02-2.48, p = 0.042). No sig-nificant gene-gene interaction between CHAT and APOE was found in GMDR method(testing balanced accuracy = 0.540, p = 0.055).
Conclusion：The CHAT A allele was associated with MCI risk in the Korean elderly. Its interaction with the APOE ε4 allele was not significant with regard to the development of MCI.

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