麝香 및 麝香 配合 韓藥製劑의 口腔 投與가 白鼠의 記憶 및 腦機能 活性에 미치는 영향 (The Effects of Moschus and Herbal Combination with Moschus by Oral Administration at Memory and Activation of Brain Ability on Rats)

서지정보

· 발행기관 : 대한한방소아과학회
· 수록지 정보 : 대한한방소아과학회지 / 23권 / 1호 / 95 ~ 113페이지
· 저자명 : 정현주, 채중원, 이유경

초록

Objectives
This study was investigated to find how the orally administrated Moschus, herbal combination with Moschus, and herbal combination improves the rats’ memory and rats’ liver. These medications are generally known asthe memory improvement.
Methods
This study used the Sprague Dawley rats. They were divided into two groups – SD rats and orally administrated Saline(Control group). 0.473 mg/kg Moschus(HM-A), 153.9 ㎎/㎏ herbal composition without Moschus(HM-B), and 165.95 ㎎/㎏ herbal composition with Moschus combined(HM-C) Control, saline were orally administered. Each group was trained in the eight-arm radial maze task at the conditions of before oral administrated, and also right after third, sixth, and eighth by oral administration. Lastly, these animals were killed and were tested for brain tissue and serum AST/ALT level to measure how the medications were effected to the liver function.
Results
The result of radial eight-arm maze task test, the HM-B and HM-C groups showed significant decrease in mistakes from the fourth day of testing. Whereas, the HM-A group showed increasing in the error rate. HM-A and HM-C group of rats had significantly increased amount of acetylcholinesterase in the CA1 region of hippocampus, compared to the control group. Whereas, HM-B and HM-C group had increased level of ChAT compared to the control group. On the other hand, each experimental group did not show any significant difference to the level of serum AST/ALT and the weight ratio of the liver to the body.
Conclusions
This study provided evidences that the orally administered memory improvement herbal medication, and Moschus were effective to improve memory.

영어초록

Objectives
This study was investigated to find how the orally administrated Moschus, herbal combination with Moschus, and herbal combination improves the rats’ memory and rats’ liver. These medications are generally known asthe memory improvement.
Methods
This study used the Sprague Dawley rats. They were divided into two groups – SD rats and orally administrated Saline(Control group). 0.473 mg/kg Moschus(HM-A), 153.9 ㎎/㎏ herbal composition without Moschus(HM-B), and 165.95 ㎎/㎏ herbal composition with Moschus combined(HM-C) Control, saline were orally administered. Each group was trained in the eight-arm radial maze task at the conditions of before oral administrated, and also right after third, sixth, and eighth by oral administration. Lastly, these animals were killed and were tested for brain tissue and serum AST/ALT level to measure how the medications were effected to the liver function.
Results
The result of radial eight-arm maze task test, the HM-B and HM-C groups showed significant decrease in mistakes from the fourth day of testing. Whereas, the HM-A group showed increasing in the error rate. HM-A and HM-C group of rats had significantly increased amount of acetylcholinesterase in the CA1 region of hippocampus, compared to the control group. Whereas, HM-B and HM-C group had increased level of ChAT compared to the control group. On the other hand, each experimental group did not show any significant difference to the level of serum AST/ALT and the weight ratio of the liver to the body.
Conclusions
This study provided evidences that the orally administered memory improvement herbal medication, and Moschus were effective to improve memory.

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