쯔쯔가무시병에 의한 수막염의 임상양상 및 뇌척수액 소견 (Tsutsugamushi Disease with Meningitis: Clinical Features and Cerebrospinal Fluid Findings)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 24권 / 2호 / 125 ~ 129페이지
· 저자명 : 김광수, 김민정

초록

Background: Tsutsugamushi disease involves the central nervous system in almost all patients and can result in meningitis. The aim of this study is to evaluate the clinical and cerebrospinal fluid (CSF) characteristics in patients with tsutsugamushi disease presenting with meningitis.
Methods: Patients, diagnosed with tsutsugamushi disease with meningitis who attended Kosin University Gospel Hospital during a period of 10 years from December 1999 to November 2009, were studied retrospectively. The clinical recordings of patients were reviewed.
Results: Ten patients(9.8%) with meningitis were recruited from 102 patients with tsutsugamushi disease. Most patients with tsutsugamushi disease with meningitis were occurred in November. The mean age was 70.7±7.7 years old, and women were six. All patients had a fever and a headache. Eschar and rash were found in 5 patients respectively. Mental change was observed in 5 patients. CSF profiles showed mild to moderate pleocytosis with predominant lymphocytes, moderately elevated protein levels, and mildly decreased glucose levels.
Conclusion: Tsutsugamushi disease with meningitis should be suspected in clinically suspicious aseptic or tuberculous meningitis occurring in the late fall. CSF findings of tsutsugamushi disease with meningitis were similar to those of tuberculous meningitis. However CSF glucose levels decreased mildly.

영어초록

Background: Tsutsugamushi disease involves the central nervous system in almost all patients and can result in meningitis. The aim of this study is to evaluate the clinical and cerebrospinal fluid (CSF) characteristics in patients with tsutsugamushi disease presenting with meningitis.
Methods: Patients, diagnosed with tsutsugamushi disease with meningitis who attended Kosin University Gospel Hospital during a period of 10 years from December 1999 to November 2009, were studied retrospectively. The clinical recordings of patients were reviewed.
Results: Ten patients(9.8%) with meningitis were recruited from 102 patients with tsutsugamushi disease. Most patients with tsutsugamushi disease with meningitis were occurred in November. The mean age was 70.7±7.7 years old, and women were six. All patients had a fever and a headache. Eschar and rash were found in 5 patients respectively. Mental change was observed in 5 patients. CSF profiles showed mild to moderate pleocytosis with predominant lymphocytes, moderately elevated protein levels, and mildly decreased glucose levels.
Conclusion: Tsutsugamushi disease with meningitis should be suspected in clinically suspicious aseptic or tuberculous meningitis occurring in the late fall. CSF findings of tsutsugamushi disease with meningitis were similar to those of tuberculous meningitis. However CSF glucose levels decreased mildly.

참고자료

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