단일기관에서 조사한 소아 뇌농양의 임상양상(1997-2006) (Clinical Features of Brain Abscesses in Neonates and Children: A Single Center Experience from 1997 to 2006)

서지정보

· 발행기관 : 대한소아감염학회
· 수록지 정보 : Pediatric Infection and Vaccine / 15권 / 1호 / 29 ~ 34페이지
· 저자명 : 이택진, 전진경, 김기환, 김기주, 김동수

초록

Purpose : We evaluated clinical presentations of brain abscesses, including predisposing
factors, causative organisms, and mortality rate in neonates and children.
Methods : We retrospectively reviewed the medical charts of neonates and children with
brain abscesses treated at Severance Hospital from January 1997 through December 2006.
Results : Among 27 neonates and children with brain abscesses, overall mortality was 22
% and 38% of survivors developed neurologic sequelae. The mortality rate was 38% in 8
infants with brain abscesses. The most common location of brain abscesses were frontal
and parietal lobes, followed by temporal lobe. There were 7 cases with multiple brain abscesses.
Streptococci (33%), Staphylococci (27%), and Gram-negative enterics (20%) were
commonly isolated. The common predisposing conditions were neurosurgical procedure (30
%), cyanotic congenital heart disease (15%), and sinusitis/otitis (7%). Fever (74%), headache
(37%), nausea/vomiting (33%), and altered mental status (33%) occurred commonly.
Compared with children older than 1 year of age, infants were associated with multiple
brain abscesses (63%, P=0.011) and high rates of death or neurologic sequelae (88%, P=
0.033).
Conclus ion : We should have a high index of suspicion in order to recognize the condition
as early as possible, especially in infancy with brain abscesses who presents vague
or nonspecific symptoms and signs. (Korean J Pediatr Inf ect D is 2008;15:29-34)

영어초록

Purpose : We evaluated clinical presentations of brain abscesses, including predisposing
factors, causative organisms, and mortality rate in neonates and children.
Methods : We retrospectively reviewed the medical charts of neonates and children with
brain abscesses treated at Severance Hospital from January 1997 through December 2006.
Results : Among 27 neonates and children with brain abscesses, overall mortality was 22
% and 38% of survivors developed neurologic sequelae. The mortality rate was 38% in 8
infants with brain abscesses. The most common location of brain abscesses were frontal
and parietal lobes, followed by temporal lobe. There were 7 cases with multiple brain abscesses.
Streptococci (33%), Staphylococci (27%), and Gram-negative enterics (20%) were
commonly isolated. The common predisposing conditions were neurosurgical procedure (30
%), cyanotic congenital heart disease (15%), and sinusitis/otitis (7%). Fever (74%), headache
(37%), nausea/vomiting (33%), and altered mental status (33%) occurred commonly.
Compared with children older than 1 year of age, infants were associated with multiple
brain abscesses (63%, P=0.011) and high rates of death or neurologic sequelae (88%, P=
0.033).
Conclus ion : We should have a high index of suspicion in order to recognize the condition
as early as possible, especially in infancy with brain abscesses who presents vague
or nonspecific symptoms and signs. (Korean J Pediatr Inf ect D is 2008;15:29-34)

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