양극산화와 석회화 순환 처리에 의해 표면개질된 Ti-6Al-4V 합금 임플란트의 생체활성도 및 골유착 평가 (Evaluation of bioactivity and osseointegration for ti-6al-4v alloy implant modified by anodic oxidation and cyclic precalcification treatments)

서지정보

· 발행기관 : 대한치과재료학회
· 수록지 정보 : 대한치과재료학회지 / 46권 / 1호 / 43 ~ 52페이지
· 저자명 : 장용석, 강재연, 이강규, 임청하, 이민호, 배태성

초록

본 연구에서는 양극산화와 석회화 순환처리된 Ti–6Al–4V 합금 임플란트의 생체활성도와 골유착을 조사하였다.
Ti-6Al-4V 합금 임플란트 표면에 수산화인회석(Hydroxyapatite; HAp) 분말을 사용하여 분사처리(Resorbable Blasting Media, RBM)를 한 후, 양극산화처리와 순환침적처리를 통해 나노튜브 타이타늄 산화층(TiO2)와 HAp 석출물을 형성하였다. 생체활성도를 조사하기 위해 표면처리된 임플란트를 유사체액 내에서 3일간 침적하고서 표면형상을 조사하였으며, 표면처리가 골결합에 미치는 영향을 조사하기 위해, RBM 처리한 임플란트와 RBM 처리-양극산화처리-석회화순환처리(RACP)를 시행한 임플란트를 쥐의 양쪽 tibia diaphysis의 원심쪽에 식립한 후, 4주 후 임플란트를 제거할 때의 토크를측정하였다. RACP 처리된 임플란트의 표면에서는 SBF 3일 침적 후 골유사 아파타이트가 석출된 것이 관찰되었다.
또한, RBM 처리군 보다 RACP 처리군에서 removal torque가 유의하게 높게 나타났으며, RBM 처리군의 표면에서는신생골과 임플란트 사이의 계면 파절을 보였지만, RACP 처리군에서는 신생골의 응집파절 및 신생골과 임플란트 사이의계면파절이 혼재하는 양상을 보였다.

영어초록

The aim of this study was to examine the bioactivity and osseointegration of Ti-6Al-4V alloy implant which was modified by an anodic oxidation and a cyclic precalcification treatments. After blasting treatment using HAp (Hydroxyapatitie; HAp) powder which is resorbable blasting media (RBM) on the surface of Ti-6Al-4V alloy implants, the anodic oxidation treatment and the cyclic precalcification treatment were conducted to form nanotube TiO2 layer and HAp precipitation respectively. The surface morphology of the surface-treated Ti-6Al-4V alloy implant was investigated after immersion in the simulated body fluid(SBF) for 3 days to investigate the bioactivity. To investigate the effect of surface treatment on bonding between the implant and bone, RBM treated implant and RBM-anodization-cyclic precalcification(RACP) treated implant were placed on the distal side of both tibia diaphysis of rats, and then the removal torque of the implant was measured after 4 weeks. On the surface of RACP treated group, bone-like apatite precipitation was observed after immersion in SBF for 3 days. The removal torque was significantly higher in the RACP treated group than in the RBM treated group. The interfacial fracture between the implant and the new bone was observed in the RBM treated group, but both the cohesive fracture at the new bone and the interfacial fractures between the implant and the new bone were observed in the RACP treated group.

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