국소 조각 골을 이용한 후방 추체간 유합술에서 탈무기질화 골기질의 이식골 강화제로서의 효과 (The Effect of Demineralized Bone Matrix as a Graft Enhancer in Posterior Lumbar Interbody Fusion Using Cage and Local Bone Chips)

서지정보

· 발행기관 : 대한척추외과학회
· 수록지 정보 : 대한척추외과학회지 / 15권 / 3호 / 157 ~ 164페이지
· 저자명 : 최대정, 안동기, 이송, 박훈석, 전영원, 양승진, 류창욱

초록

Study design: A randomized, controlled study
Objectives: We wanted to investigate whether osteogenesis can be enhanced when a small amount of demineralized bone
matrix (1 cc/segment) is mixed with local bone chips.
Summary of the Literature Review: Demineralized bone matrix (DBM) has been used for spinal arthrodesis. However, there are
only a few reports about its use as a composite graft with local bone chips for posterior lumbar interbody fusion
Materials and Methods: Degenerative spine patients, who would normally be treated by decompression and posterior lumbar
interbody fusion with using a pedicle screw system and one cage, were randomly, prospectively selected for whether they would
be treated with using local bone chips mixed with 1cc of DBM (Group I: 15 patients and 19 segments) or local bone chips (Group
II: 12 patients and 13 segments) for graft material. The sampling bias was investigated for gender, age, endocrine diseases, previous
operation, habits (alcohol drinking, smoking), steroid medication, bone mineral density and the amount of local bone. The
amount of bone formation was measured at 6 months after operation. On the sagittal and coronal reconstruction CT images, the
bone formation outside of the cage was measured, and this was interpreted in a “blinded”fashion by 2 independent doctors
who did not take part in the operations.
Results: There was no sampling bias between the 2 groups except for age (Group I= 65.3±7.1, Group II=58.9±6.0, p=0.010). The
ratio of local bone chips and DBM was 5.98:1 in Group I. There was moderate concurrence between the 2 interpreters (kappa coefficiency=
0.494, p<0.001 for the sagittal plain images and kappa co-efficiency=0.467, p<0.001 for the coronal plain images) and
Group I showed significantly more bone formation (p=0.003).
Conclusion: DBM that is mixed with local bone chips, even with small amount, enhanced bone formation in the posterior lumbar
interbody fusion. This is regarded to act as a graft enhancer to increase the fusion rate, even when using local bone chips
for graft material, for the cases that show unfavorable conditions for fusion or for the cases that are prone to loosening of
hardware.

영어초록

Study design: A randomized, controlled study
Objectives: We wanted to investigate whether osteogenesis can be enhanced when a small amount of demineralized bone
matrix (1 cc/segment) is mixed with local bone chips.
Summary of the Literature Review: Demineralized bone matrix (DBM) has been used for spinal arthrodesis. However, there are
only a few reports about its use as a composite graft with local bone chips for posterior lumbar interbody fusion
Materials and Methods: Degenerative spine patients, who would normally be treated by decompression and posterior lumbar
interbody fusion with using a pedicle screw system and one cage, were randomly, prospectively selected for whether they would
be treated with using local bone chips mixed with 1cc of DBM (Group I: 15 patients and 19 segments) or local bone chips (Group
II: 12 patients and 13 segments) for graft material. The sampling bias was investigated for gender, age, endocrine diseases, previous
operation, habits (alcohol drinking, smoking), steroid medication, bone mineral density and the amount of local bone. The
amount of bone formation was measured at 6 months after operation. On the sagittal and coronal reconstruction CT images, the
bone formation outside of the cage was measured, and this was interpreted in a “blinded”fashion by 2 independent doctors
who did not take part in the operations.
Results: There was no sampling bias between the 2 groups except for age (Group I= 65.3±7.1, Group II=58.9±6.0, p=0.010). The
ratio of local bone chips and DBM was 5.98:1 in Group I. There was moderate concurrence between the 2 interpreters (kappa coefficiency=
0.494, p<0.001 for the sagittal plain images and kappa co-efficiency=0.467, p<0.001 for the coronal plain images) and
Group I showed significantly more bone formation (p=0.003).
Conclusion: DBM that is mixed with local bone chips, even with small amount, enhanced bone formation in the posterior lumbar
interbody fusion. This is regarded to act as a graft enhancer to increase the fusion rate, even when using local bone chips
for graft material, for the cases that show unfavorable conditions for fusion or for the cases that are prone to loosening of
hardware.

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