백서 두개골 결손부에서 동결건조골과 gel/putty 형 탈회골기질의 골재생효과 (The effect of the freeze dried bone allograft and gel/putty type demineralized bone matrix on osseous regeneration in the rat calvarial defects)

서지정보

· 발행기관 : 대한치주과학회
· 수록지 정보 : Journal of Periodontal & Implant Science / 39권 / 3호 / 349 ~ 358페이지
· 저자명 : 김득한, 홍지연, 방은경

초록

Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix
on osseous regeneration in the rat calvarial defects.
Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided
into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss
™
),
Demineralized Bone Matrix(ExFuse
™
Gel, ExFuse
™
Putty), or were left untreated for sham-surgery control and were evaluated
by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was
done between each groups and time intervals with ANOVA and paired t-test.
Results: Defect closure, New bone area, Augmented area in the SureOss
™
, ExFuse
™
Gel, ExFuse
™
Putty groups were
significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and
Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse
™
Gel,
ExFuse
™
Putty groups were significantly greater than SureOss
™
group at 2weeks(P < 0.05), however there was no significant
difference at 8 weeks.
Conclusions: All of SureOss
™
, ExFuse
™
Gel, ExFuse
™
Putty groups showed significant new bone formation and augmentation
in the calvarial defect model. (J Korean Acad Periodontol 2009;39:349-358)

영어초록

Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix
on osseous regeneration in the rat calvarial defects.
Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided
into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss
™
),
Demineralized Bone Matrix(ExFuse
™
Gel, ExFuse
™
Putty), or were left untreated for sham-surgery control and were evaluated
by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was
done between each groups and time intervals with ANOVA and paired t-test.
Results: Defect closure, New bone area, Augmented area in the SureOss
™
, ExFuse
™
Gel, ExFuse
™
Putty groups were
significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and
Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse
™
Gel,
ExFuse
™
Putty groups were significantly greater than SureOss
™
group at 2weeks(P < 0.05), however there was no significant
difference at 8 weeks.
Conclusions: All of SureOss
™
, ExFuse
™
Gel, ExFuse
™
Putty groups showed significant new bone formation and augmentation
in the calvarial defect model. (J Korean Acad Periodontol 2009;39:349-358)

참고자료

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