한국인 난소암 조직에서 발현된 miRNA의 타겟 mRNA를 중심으로 하는 p53 관련 신호전달 체계 분석 (p53 Associated Signaling Pathway Analysis in Terms of microRNAs and Their Target mRNAs in Korean Ovarian Cancer Tissues)

서지정보

· 발행기관 : 대한암예방학회
· 수록지 정보 : 대한암예방학회지 / 15권 / 3호 / 236 ~ 240페이지
· 저자명 : 권지영, 배수미, 안웅식, 김정민, 서영록

초록

Ovarian cancer has been considered as the mostly common cancer among women in worldwide.
Molecular mechanism of initiation and progression in this cancer has been well studied, however, diagnotic and therapeutic programs has not been successfully established yet. In order to improve screening program to detect the ovarian cancer at the early stage and subsequently develop therapeutic modalities for cancer treatment, research focusing on more insight of regulatory molecular mechanisms are urgently required.
Here, we analyze effect of microRNAs (miRNAs), recognized as non-coding RNAs that negatively regulate expression of target genes, on gene expression at genome wide level. Concerning with potential miRNA features, each miRNA is able to inhibit hundreds of transcripts directly or indirectly. Therefore,signaling network analysis of miRNA targeting on particular mRNA would provide novel molecular interactions for establishing alternative approach to treat the ovarian cancer patients. Our group has analyzed miRNA microarray in ovarian tissues from Korean patients. Based on our previous microarray study, we discovered miRNA-associated target mRNAs participating in p53-regulated signaling. As result,we have presented 26 target genes related with p53-controlling pathway. Interestingly, the identified three genes encoding ING1, NDRG1 and CDC14A might be further recognized as novel target molecules in ovarian cancer. This study might provide evidence for better understanding mechanism in relevance to governing ovarian cancer and consequently for improving diagnosis and therapy of this cancer.

영어초록

Ovarian cancer has been considered as the mostly common cancer among women in worldwide.
Molecular mechanism of initiation and progression in this cancer has been well studied, however, diagnotic and therapeutic programs has not been successfully established yet. In order to improve screening program to detect the ovarian cancer at the early stage and subsequently develop therapeutic modalities for cancer treatment, research focusing on more insight of regulatory molecular mechanisms are urgently required.
Here, we analyze effect of microRNAs (miRNAs), recognized as non-coding RNAs that negatively regulate expression of target genes, on gene expression at genome wide level. Concerning with potential miRNA features, each miRNA is able to inhibit hundreds of transcripts directly or indirectly. Therefore,signaling network analysis of miRNA targeting on particular mRNA would provide novel molecular interactions for establishing alternative approach to treat the ovarian cancer patients. Our group has analyzed miRNA microarray in ovarian tissues from Korean patients. Based on our previous microarray study, we discovered miRNA-associated target mRNAs participating in p53-regulated signaling. As result,we have presented 26 target genes related with p53-controlling pathway. Interestingly, the identified three genes encoding ING1, NDRG1 and CDC14A might be further recognized as novel target molecules in ovarian cancer. This study might provide evidence for better understanding mechanism in relevance to governing ovarian cancer and consequently for improving diagnosis and therapy of this cancer.

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