Collagen을 포함한 생체 친화성 및 고기능성 하이드로겔 렌즈의 제조 및 특성 (Preparation and Characterization of Biocompatible and High Functional Hydrogel Lenses Containing Collagen Material)

서지정보

· 발행기관 : 대한시과학회
· 수록지 정보 : 대한시과학회지 / 24권 / 1호 / 43 ~ 50페이지
· 저자명 : 허지원, 신수미, 김달원, 성아영

초록

목적: 본 연구는 Polydimethylsiloxane(PDMS)를 기반으로 다양한 첨가제를 사용하여 고 기능성 안 의료용고분자를 제조한 후, 제조된 렌즈 표면에 생체적합성 및 습윤성이 우수한 collagen을 코팅하여 물성을 비교 분석하였다.
방법: 렌즈 제조를 위해 PDMS와 친수성 모노머인 N,N-dimethylacrylamide(DMA), 2-Hydroxyethyl methacrylate(HEMA)를 주재료로 사용하였으며, 교차결합제인 Ethylene glycol dimethacrylate(EGDMA)와 열개시제인 Azobisisobutyronitrile(AIBN)을 사용하였다. 또한 기능성 첨가제로는 1,3-Bis(3-aminopropyl) tetramethyldisiloxane(TMDS), Polyvinylpyrrolidone(PVP), 2-(Trifluoromethyl)styrene 및 collagen을 사용하였다. 제조된 렌즈의 물성 평가를 위해 광투과율, 굴절률, 함수율, 산소투과율 그리고 인장강도를 각각 측정하였으며, 접촉각 측정을 통해 습윤성을 평가하였다.
결과: TMDS의 첨가비율에 따라 렌즈의 산소투과율은 약 28~45 ×10⁻¹¹(cm²/sec)(mlO²/ml×mmHg)으로나타내었으며, PVP 및 2-(Trifluoromethyl)styrene가 첨가된 렌즈의 습윤성 및 인장강도는 56~46° 그리고0.11~0.17 kgf/mm² 의 범위로 각각 나타났다. 다양한 첨가제를 사용함으로써 제조된 렌즈의 기능성이 향상되었으며, 특히 콜라겐 첨가제의 사용은 하이드로겔 표면의 접촉각을 매우 감소시켜 우수한 습윤성을 가지는 것으로나타났다.
결론: TMDS, PVP 그리고 2-(Trifluoromethyl)styrene은 실리콘 하이드로겔 렌즈의 기능성 향상에 효과적이며, 첨가제로서의 collagen 사용은 렌즈의 습윤성을 향상시키는 것으로 나타나 본 연구에서 사용된 재료는 안의료용으로 다양하게 활용될 수 있을 것으로 판단된다.

영어초록

Purpose : In this study, a high-functional ophthalmic polymer was prepared using various additives based on PDMS, and then, the prepared lens surface was coated with collagen with excellent biocompatibility and wettability to compare and analyze the physical properties.
Methods : Polydimethylsiloxane (PDMS) and hydrophilic monomers N,N-dimethylacrylamide (DMA) and 2-Hydroxyethyl methacrylate (HEMA) were used as main materials for lens manufacturing. Ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent and Azobisisobutyronitrile (AIBN) as a thermal initiator were used. In addition, 1,3-Bis (3-aminopropyl)tetramethyldisiloxane (TMDS), Polyvinylpyrrolidone (PVP), 2-(Trifluoromethyl) styrene and collagen were used as functional additives. Light transmittance, refractive index, water content, oxygen transmittance, and tensile strength were respectively measured to evaluate the physical properties of the manufactured lens, and wettability was evaluated by measuring the contact angle.
Results : The addition of TMDS showed the oxygen transmittance of the lens as about 28 to 45×10⁻¹¹(cm²/sec)(mlO²/ml×mmHg) depending on the addition ratio. In addition, the addition of PVP and 2-(Trifluoromethyl)styrene showed the wettability and tensile strength of the lens as about 56~46° and about 0.11~0.17 kgf/mm² depending on the addition ratio, respectively. It was found that the functionality of the manufactured lens was improved by using various additives, and in particular, the use of the collagen additive, the contact angle of the surface of the hydrogel was greatly reduced to have excellent wettability.
Conclusion : Therefore, TMDS, PVP and 2-(Trifluoromethyl)styrene are effective in improving the functionality of silicone hydrogel lenses, and the use of collagen as an additive improves the wettability of lenses.

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