가토의 두개골에서 티타늄 반구를 이용한 다양한 onlay bone graft시 골형성 능력 (THE EFFECT OF NEW BONE FORMATION OF ONLAY BONE GRAFT USING VARIOUS GRAFT MATERIALS WITH A TITANIUM CAP ON THE RABBIT CALVARIUM)

서지정보

· 발행기관 : 대한악안면성형재건외과학회
· 수록지 정보 : Maxillofacial Plastic Reconstructive Surgery / 31권 / 6호 / 469 ~ 477페이지
· 저자명 : 박영준, 최근호, 유민기, 국민석, 박홍주, 유선열, 오희균, 장정록, 정승곤, 한만승

초록

Purpose: This study was performed to evaluate the effect of various graft materials used with a titanium
cap on the ability of new bone formation in the rabbit calvarium.
Materials and Methods: A total of 32 sites of artificial bony defects were prepared on the calvaria of
sixteen rabbits by using a trephine bur 8 mm in diameter. Each rabbit had two defect sites. 0.2 mm deep
grooves were formed on the calvaria of sixteen rabbits by using a trephine bur 8 mm in diameter for the
fixation of a titanium cap. The treatments were performed respectively as follows: without any graft for the
control group (n=8), autogenous iliac bone graft for experimental group 1 (n=8), alloplastic bone graft
(SynthoGraft®, USA) for experimental group 2 (n=8), and xenogenic bone graft (NuOss®, USA) for experimental
group 3 (n=8). After the treatments, a titanium cap (8 mm in diameter, 4 mm high, and 0.2 mm
thick) was fixed into the groove. At the third and sixth postoperative weeks, rabbits in each group were
sacrificed for histological analysis.
Results: 1. In gross examination, the surgical sites showed no signs of inflammation or wound dehiscence,
and semicircular-shaped bone remodeling was shown both in the experimental and control groups.
2. In histological analysis, the control group at the third week showed bone remodeling along the inner
surface of the cap and at the contact region of the calvarium without any specific infiltration of inflammation
tissue. Also, there was no soft tissue infiltration. Bone remodeling was observed around the grafted
bone and along the inner surface of the titanium cap in experimental group 1, 2, and 3.
3. Histologically, all groups at the sixth week showed the increased area of bone remodeling and maturation
compared to those at the third week. In experimental group 2, the grafted bone was partially absorbed
by multi nucleated giant cells and new bone was formed by osteoblasts. In group 3, however, resorption of
the grafted bone was not observed.
4. Autogenous bone at the third and sixth week showed the most powerful ability of new bone formation.
The size of newly formed bone was in decreasing order by autogenous, alloplastic, and heterogenous bone
graft. There was no statistically significant difference among autogenous, alloplastic, and heterogenous
bones(p>0.05).
Summary: This result suggests that autogenous bone is the best choice for new bone formation, but
when autogenous bone graft is in limited availability, alloplastic and xenogenic bone graft also can be an
alternative bone graft material to use with a suitably guided membrane.

영어초록

Purpose: This study was performed to evaluate the effect of various graft materials used with a titanium
cap on the ability of new bone formation in the rabbit calvarium.
Materials and Methods: A total of 32 sites of artificial bony defects were prepared on the calvaria of
sixteen rabbits by using a trephine bur 8 mm in diameter. Each rabbit had two defect sites. 0.2 mm deep
grooves were formed on the calvaria of sixteen rabbits by using a trephine bur 8 mm in diameter for the
fixation of a titanium cap. The treatments were performed respectively as follows: without any graft for the
control group (n=8), autogenous iliac bone graft for experimental group 1 (n=8), alloplastic bone graft
(SynthoGraft®, USA) for experimental group 2 (n=8), and xenogenic bone graft (NuOss®, USA) for experimental
group 3 (n=8). After the treatments, a titanium cap (8 mm in diameter, 4 mm high, and 0.2 mm
thick) was fixed into the groove. At the third and sixth postoperative weeks, rabbits in each group were
sacrificed for histological analysis.
Results: 1. In gross examination, the surgical sites showed no signs of inflammation or wound dehiscence,
and semicircular-shaped bone remodeling was shown both in the experimental and control groups.
2. In histological analysis, the control group at the third week showed bone remodeling along the inner
surface of the cap and at the contact region of the calvarium without any specific infiltration of inflammation
tissue. Also, there was no soft tissue infiltration. Bone remodeling was observed around the grafted
bone and along the inner surface of the titanium cap in experimental group 1, 2, and 3.
3. Histologically, all groups at the sixth week showed the increased area of bone remodeling and maturation
compared to those at the third week. In experimental group 2, the grafted bone was partially absorbed
by multi nucleated giant cells and new bone was formed by osteoblasts. In group 3, however, resorption of
the grafted bone was not observed.
4. Autogenous bone at the third and sixth week showed the most powerful ability of new bone formation.
The size of newly formed bone was in decreasing order by autogenous, alloplastic, and heterogenous bone
graft. There was no statistically significant difference among autogenous, alloplastic, and heterogenous
bones(p>0.05).
Summary: This result suggests that autogenous bone is the best choice for new bone formation, but
when autogenous bone graft is in limited availability, alloplastic and xenogenic bone graft also can be an
alternative bone graft material to use with a suitably guided membrane.

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