Current Status of the Management Program for Animal Model of Disease in an Advanced Country (Current Status of the Management Program for Animal Model of Disease in an Advanced Country)

서지정보

· 발행기관 : 한국실험동물학회
· 수록지 정보 : Laboratory Animal Research / 25권 / 1호 / 79 ~ 85페이지
· 저자명 : Yoen Kyung Lee, Seung Eun Jung, Ji Ha Kim, 김지은, 강현구, Jung Sik Cho, 서준교, 황대연

초록

Animal models of disease are animals that mimic the pathological condition or the disease entity of
specific diseases occurring in humans. These animals are very useful to screen drugs that may be
harmful, have a side effect, or would allow a better understanding of the disease mechanism. This study
surveyed the current situation of animal care and use program for the Genetic Engineered Mouse (GEM)
in the possession of advanced country. Also, the items of these situation involved the GEM number, the
national policy and the government support system. The largest number of disease animals in the world
is maintained in the USA. Specifically, the National Institute of Health (NIH) in USA supports the several
institutions such as Mutant Mouse Regional Resource Centers (MMRRC), Induced Mutant Resource (IMR),
Mouse Mutant Gene Resource (MMR), Special Mouse Strains Resource (SMSR) and Neuromice (NMICE)
to maintain the animal models of disease. In Japan, RIKEN BioResource Center as one of several
resources centers is collecting, supplying and reserving GEM involving the animal models of disease.
These works were supported by National BioResource Project (NBRP) of Japanese government. Finally, the
some countries in the European Union compile theEuropean Mouse Mutant Archive (EMMA) in order to
effectively support and manage these animal models of disease. At present, EMMA possesses 800 kinds
of GEM disease models. Therefore, these results suggested that it is very important to establish the
national management program for animal model of disease, and this system must be established as soon
as possible in our country.

영어초록

Animal models of disease are animals that mimic the pathological condition or the disease entity of
specific diseases occurring in humans. These animals are very useful to screen drugs that may be
harmful, have a side effect, or would allow a better understanding of the disease mechanism. This study
surveyed the current situation of animal care and use program for the Genetic Engineered Mouse (GEM)
in the possession of advanced country. Also, the items of these situation involved the GEM number, the
national policy and the government support system. The largest number of disease animals in the world
is maintained in the USA. Specifically, the National Institute of Health (NIH) in USA supports the several
institutions such as Mutant Mouse Regional Resource Centers (MMRRC), Induced Mutant Resource (IMR),
Mouse Mutant Gene Resource (MMR), Special Mouse Strains Resource (SMSR) and Neuromice (NMICE)
to maintain the animal models of disease. In Japan, RIKEN BioResource Center as one of several
resources centers is collecting, supplying and reserving GEM involving the animal models of disease.
These works were supported by National BioResource Project (NBRP) of Japanese government. Finally, the
some countries in the European Union compile theEuropean Mouse Mutant Archive (EMMA) in order to
effectively support and manage these animal models of disease. At present, EMMA possesses 800 kinds
of GEM disease models. Therefore, these results suggested that it is very important to establish the
national management program for animal model of disease, and this system must be established as soon
as possible in our country.

참고자료

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