Streptozotocin 유발 당뇨 쥐에서 대두와 청국장 및 Poly-γ-Glutamic Acid 분말식이의 항당뇨 효과 (Antidiabetic Effect of Soybean and Chunggukjang, γ-PGA powder diet in Streptozotocin-Induced Diabetic Rats)

서지정보

· 발행기관 : 한국엔터테인먼트산업학회
· 수록지 정보 : 한국엔터테인먼트산업학회논문지 / 7권 / 3호 / 264 ~ 277페이지
· 저자명 : 문진아, 왕수경, 오선영

초록

본 연구는 콩식이에 따른 항당뇨 효능 실험으로 성인들의 당뇨예방 및 치료에 도움을 주고자 하는 목적으로 날콩, 볶은콩, 청국장과 γ-PGA 분말을 AIG-93G에 첨가한 식이를 STZ로 유발된 당뇨 흰쥐에게 4주간 섭취시킨 후 혈당, 지질함량 및 장기무게에 미치는 영향을 분석하였다. 실험결과는 PASW를 이용하여 평균, 표준편차를 구하였고, One-way analysis of variance tset를 한 후 각 실험군간의 유의차 검증을 확인하였으며, 다음과 같은 결과를 얻었다. 첫째, 실험동물의 체중변화는 당뇨유발 후 정상군 이외의 모든 군이 유의적으로 감소하였으며, 날콩군과 γ-PGA군은 당뇨대조군에 비해 체중이 증가하였다. 둘째, 간장과 신장 좌․우 장기무게의 경우 정상군에 비해 모든 당뇨유발군은 증가하였다. 셋째, 혈중 포도당의 농도를 측정 한 결과 당뇨유발 후 정상군보다 모든 당뇨유발군이 혈당이 증가하였으며, γ-PGA군과 날콩군은 유의적으로 낮은 혈당 수준을 보여주었다. 넷째, 실험 5주째 희생 후 측정한 혈청 총 중성지방은 γ-PGA군에 비해 모든 군들 또한 유의적으로 감소하였다. 다섯째, 간장의 단백질 함량은 정상군에 비해 모든 당뇨유발군이 높았고, 당뇨군에 비해 모든 실험군이 유의적으로 높았다. .

영어초록

In this research, the influence that it reaches to the blood sugar and lipid content and internal organ weight after during 4 weeks to the diabetes white rat caused the diet adding the unroasted bean, roasted bean, chunggukjang and γ-PGA powder as the experiment looking at the antidiabetic effect according to a diet to AIG-93G by STZ was analyzed. 1) As to the weight change of the experimental animal, the weight increased the unroasted bean group and γ-PGA group in comparison with the streptozotocin-induced group. As to the diet intake, the chunggukjang and γ-PGA group increased by a significant in comparison with the diabetes group. 2) When converting the weight of an organ into the weight 100 g per, all diabetes induced group are considered that they increased in case of the extension liver and kidney left ․ right internal organ weight in comparison with the normal group but show up in case of the unroasted bean and that the weight of an organ is low for a significant the portliness of bowels and intestines and extension is suppressed. 3) All diabetes induced groups picked up to the blood sugar after the diabetes induction more than the normal group as a result of measuring the concentration of the blood glucose. And γ-PGA group and unroasted bean group showed the blood sugar level which is low for a significant. As to C-peptide, the reduction of the unroasted bean group and γ-PGA group shows the low tendency. This can control the hyperglycemia symptom of the diabetes. 4) The lipid content was measured. Then, γ-PGA group was highest as to serum triglyceride, measured after an experiment 5 weeks sacrifice. As to the neutral lipid of the hepatic tissue, the unroasted bean group was lowest. In the case of the blood serum total cholesterol, the chunggukjang group showed the high tendency. 5) As to the protein content of the liver, all experimental groups were higher than the diabetes group as a significant. In the case of the content of the glycogen, the unroasted bean group was not a significant but it was highest. Therefore, there were the unroasted bean, roasted bean and antidiabetic effect of the chunggukjang γ-PGA. Because particularly, the antidiabetic effect of γ-PGA was high and there seemed to be an effect with the diabetes prevention and therapeutic diet.

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