Autophagy: a lysosomal degradation process for cellular homeostasis and its relationship with oral squamous cell carcinoma

서지정보

· 발행기관 : 대한구강생물학회
· 수록지 정보 : International Journal of Oral Biology / 46권 / 2호
· 저자명 : Junyoung Jung, Joungmok Kim, Jeong Hee Kim

목차

Introduction
Three Types of Autophagy
Molecular Mechanism of AutophagosomeBiogenesis
1. Initiation and nucleation: ULK1 and VPS34 complex
2. Elongation and completion of autophagosomalmembrane: ATG5-ATG12-ATG16L and LC3conjugation system
Autophagy and Oral Cancer
Chemicals and Natural Products Involvedin Autophagic Cell Death of OSCC
Conclusions
References

영어초록

Autophagy is an evolutionarily well-conserved cellular homeostasis program that responds to various cellular stresses and degrades unnecessary or harmful intracellular materials in lysosomes. Accumulating evidence has shown that autophagy dysfunction often results in various human pathophysiological conditions, including metabolic disorders, cancers, and neurodegenerative diseases. The discovery of an autophagy machinery protein network has revealed underlying molecular mechanisms of autophagy, and advances in the understanding of its regulatory mechanism have provided novel therapeutic targets for treating human diseases. Recently, reports have emerged on the involvement of autophagy in oral squamous cell carcinoma (OSCC). Although the role of autophagy in cancer therapy is controversial, the beneficial use of the induction of autophagic cell death in OSCC has drawn significant attention. In this review, the types of autophagy, mechanism of autophagosome biogenesis, and modulating molecules and therapeutic candidates affecting the induction of autophagic cell death in OSCC are briefly described.

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