포유동물 생식세포 및 생식기관에서 발현되는 Two-Pore Domain 칼륨 통로

서지정보

· 발행기관 : 한국수정란이식학회
· 수록지 정보 : Journal of Embryo Transfer / 24권 / 3호
· 저자명 : 이효진, 한재희, 강다원

초록

Two-pore domain 칼륨() 통로는 흥분세포 및 비흥분세포의 안정막 전압을 일정하게 유지하는데 관여한다. 그러나 생식세포 및 생식기관에서 발현되는 통로의 분포영역 및 그 기능에 대해서는 연구자들에 의해 아직 정리되지 못하였다. 본 종설에서는 통로의 생식세포 및 생식기관에서 발현, 분포 및 생리학적 의의를 논하였다. 통로는 인간 영양막세포, 자궁근층, 태반혈관계, 자궁평활근조직, 태반융모조직 및 임신자궁조직에서 발현되어 임신에 있어서 관련성을 제

영어초록

Two-pore domain channels contribute to setting the resting membrane potential in excitable and nonexcitable cells. However, the cellular or tissue distribution and function of channels expressed in mammalian germ cells and reproductive organs have not yet been reviewed by researchers. In this review, we focus on expression, localization and expected properties of channels in germ cells and reproductive organs. The channels are expressed in human cytotrophoblast cells, myometrium, placental vascular system, uterine smooth muscle, and pregnant term tissue, suggesting that channels might be involved in the processes of pregnance. The channels are also expressed in mouse zygotes, monkey sperm, ovary, testis, germ cells, and embryos of Korean cattle. Interestingly, channels are modulated by changes in temperature and oxygen concentration which play an important role in embryonic development. Also, channels are responsible for efflux during apoptotic volume decreases in mouse zygotes. These expression patterns and properties of the channels in reproductive organs and germ cells are likely to help the understanding of ion channel-related function in reproductive physiology.

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