Analysis of Rat Mitochondrial Proteome Reveals Effects of Exercise on Tissue Specific Changes of Metabolism

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Exercise affects various physiological phenotypes such as weight loss, anti-aging, and the increasing of heart and skeletal muscle mass. However there is the shortage of researches about proteins which are correlated with such physiological phenotype and their expression. Also, there were many evidences that showed protein expression was different according to tissue and organelle. Among organelles, mitochondria have strongest relation with energy metabolism which is required by exercise. Thus, to understand exercise effects on mitochondria, we identified mitochondrial proteins of heart, brain, muscle, and liver in rat. Using identified 422 mitochondrial proteins, we analyzed expression changes. By constructing new parameter we measured the difference of expression changes among four tissues. We found that the expression of proteins having metabolic function altered tissue-specifically. Especially the decreasing of brain metabolic proteins included in glucose metabolic proteins were significantly decreased. These results show that exercise affects brain more than we expected. This study suggests the way to research exercise response and provide reliable proteomic data about exercise.

참고자료

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