첨가제에 따른 염산시부트라민 정제의 특성화 및 방출거동 (Characterization and Release Behavior of Sibtramine HCl Tablet with the Additives)

서지정보

· 발행기관 : 한국조직공학과 재생의학회
· 수록지 정보 : 조직공학과 재생의학 / 5권 / 4호 / 729 ~ 734페이지
· 저자명 : 박종학, 구정, 안식일, 이준희, 김윤태, 김대성, 김원, 이종문, 강길선

초록

In this study, sibutramine HCl, appetite suppressants were prepared into tablet type with additives such as lactose monohydrate, microcrystalline cellulose(MCC), and PVP K-25 to effective oral administration. We used the polyplasdone XL-10 as disintegrant. We compared the in vitro release behavior of sibutramine from the tablets according to additives with commercial drug, Reductil. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter(DSC). FT-IR and DSC results demonstrates that structure of drug was changed and crystallinity of drug was decreased according to additives. The dissolution rate of sibutramine HCl from tablet greatly increased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) in case of adding lactose monohydrate and PVP K-25. This study suggest that various pharmaceutical excipients could improve the sibutramine HCl release behaviors.

영어초록

In this study, sibutramine HCl, appetite suppressants were prepared into tablet type with additives such as lactose monohydrate, microcrystalline cellulose(MCC), and PVP K-25 to effective oral administration. We used the polyplasdone XL-10 as disintegrant. We compared the in vitro release behavior of sibutramine from the tablets according to additives with commercial drug, Reductil. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter(DSC). FT-IR and DSC results demonstrates that structure of drug was changed and crystallinity of drug was decreased according to additives. The dissolution rate of sibutramine HCl from tablet greatly increased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) in case of adding lactose monohydrate and PVP K-25. This study suggest that various pharmaceutical excipients could improve the sibutramine HCl release behaviors.

참고자료

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