덱스트란과 젤라틴을 고정화한 생의학용 산화철 나노입자의 제조 (Fabrication of Magnetite Nanoparticles Immobilized with Dextran and Gelatin for Biomedical Application)

서지정보

· 발행기관 : 한국생체재료학회
· 수록지 정보 : 생체재료학회지 / 12권 / 1호 / 19 ~ 23페이지
· 저자명 : 이상민, 강인규, 김선정, Haiqing Guo

초록

Superparamagnetic iron oxide nanoparticles with suitable biocompatible molecules have been widely used experimentally
for numerous in vivo applications such as magnetic resonance imaging contrast enhancement, tissue engineering,
immunoassay, detoxification of biological fluids, hyperthermia, drug delivery, and in cell separation etc.
Surface-functionalized magnetite nanoparticles are suitable for receptor targeting because of their colloidal stability,
biocompatibility, biodegradability, and non-toxicity for the body. We have prepared gelatin-immobilized magnetite
nanoparticles in order to examine their possible application to molecular imaging. The presence of gelatin on the surface
of nanoparticles was confirmed by observing amine groups using FTIR and ESCA. The size of DGNP particles measured
by TEM and DLS was about 7.5 and 25 nm, respectively. In the cell culture experiment, it is revealed that
DGNPs are more effectively uptaken by fibroblasts when compared to DNP.

영어초록

Superparamagnetic iron oxide nanoparticles with suitable biocompatible molecules have been widely used experimentally
for numerous in vivo applications such as magnetic resonance imaging contrast enhancement, tissue engineering,
immunoassay, detoxification of biological fluids, hyperthermia, drug delivery, and in cell separation etc.
Surface-functionalized magnetite nanoparticles are suitable for receptor targeting because of their colloidal stability,
biocompatibility, biodegradability, and non-toxicity for the body. We have prepared gelatin-immobilized magnetite
nanoparticles in order to examine their possible application to molecular imaging. The presence of gelatin on the surface
of nanoparticles was confirmed by observing amine groups using FTIR and ESCA. The size of DGNP particles measured
by TEM and DLS was about 7.5 and 25 nm, respectively. In the cell culture experiment, it is revealed that
DGNPs are more effectively uptaken by fibroblasts when compared to DNP.

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