통영산 해수진주분말의 체내 용해도에 관한 기초연구 (A Study on the Solubility of Pearl Powder in a Pearl's Body in Tongyeong Seawater)

서지정보

· 발행기관 : 한국도서(섬)학회
· 수록지 정보 : 한국도서연구 / 26권 / 2호 / 161 ~ 176페이지
· 저자명 : 김현걸, 이승철

초록

In order to study the movement of a pearl's body, the Tongyeong pearl powder (insoluble=pearl) and manufactured powder (soluble-pearl, solubilized in water) were used as samples. The body of a pearl contains calcuim compounds and pharmacologically activated chonchiolin. This research evaluated the water solubilization level of proteins and the solubility of pearl powder using artificial gastric juice and intestinal juice.
The analysis of the sugar content showed that no soluble or insoluble-pearl was found. This showed that carbohydrates are not the main components of the pearl. Also, in order to evaluate the water solubility level of chonchiolin, which is the only protein of the pearl, a protein quantification experiment was conducted. The result showed that no protein was found in the insoluble-pearl, which confirmed that chonchiolin was insoluble. In the soluble-pearl, protein consisted of 0.12%, and the effects of protein's acid hydrolysis in acetic acid during the water solubilization process was either none or very weak. Such results showed that the development of chonchiolin water solubilization using protease is necessary.
From the results that showed 22.7% of solubility (37℃ body temperature) at artificial gastric juice and 1.7% at artificial intestinal juice, the insoluble-peral is expected to dissolve into a small amount within the stomach(acidic environment), and rarely dissolve in the small intestine absorption area. Also, 75% of the dosage is expected to be excreted from the body. In order to find out the exact absorption level within the body of a pearl, more research on the vitro level and continuous biological tests is required.
The solubility of soluble-pearl manufactured by using insoluble-pearl powder is 32.9%, which is 1.4 fold higher than insoluble-pearl. It is 17.6% at the artificial intestinal juice and it's solubility is 10 fold higher than insoluble-pearl. The calcium carbonate inside the pearl is assumed to convert into calcium acetate, which is soluble to a certain degree during the water solubilization process. However, considering the fact that the solubility value is not as much as expected, from now on, improving the condition of the water solubilization process such as increasing reaction temperature is needed.

영어초록

In order to study the movement of a pearl's body, the Tongyeong pearl powder (insoluble=pearl) and manufactured powder (soluble-pearl, solubilized in water) were used as samples. The body of a pearl contains calcuim compounds and pharmacologically activated chonchiolin. This research evaluated the water solubilization level of proteins and the solubility of pearl powder using artificial gastric juice and intestinal juice.
The analysis of the sugar content showed that no soluble or insoluble-pearl was found. This showed that carbohydrates are not the main components of the pearl. Also, in order to evaluate the water solubility level of chonchiolin, which is the only protein of the pearl, a protein quantification experiment was conducted. The result showed that no protein was found in the insoluble-pearl, which confirmed that chonchiolin was insoluble. In the soluble-pearl, protein consisted of 0.12%, and the effects of protein's acid hydrolysis in acetic acid during the water solubilization process was either none or very weak. Such results showed that the development of chonchiolin water solubilization using protease is necessary.
From the results that showed 22.7% of solubility (37℃ body temperature) at artificial gastric juice and 1.7% at artificial intestinal juice, the insoluble-peral is expected to dissolve into a small amount within the stomach(acidic environment), and rarely dissolve in the small intestine absorption area. Also, 75% of the dosage is expected to be excreted from the body. In order to find out the exact absorption level within the body of a pearl, more research on the vitro level and continuous biological tests is required.
The solubility of soluble-pearl manufactured by using insoluble-pearl powder is 32.9%, which is 1.4 fold higher than insoluble-pearl. It is 17.6% at the artificial intestinal juice and it's solubility is 10 fold higher than insoluble-pearl. The calcium carbonate inside the pearl is assumed to convert into calcium acetate, which is soluble to a certain degree during the water solubilization process. However, considering the fact that the solubility value is not as much as expected, from now on, improving the condition of the water solubilization process such as increasing reaction temperature is needed.

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