아스파라거스 부산물 추출물의 숙취 해소 및 통풍완화 효과

서지정보

· 발행기관 : 한국약용작물학회
· 수록지 정보 : 한국약용작물학회지 / 30권 / 2호 / 145 ~ 152페이지
· 저자명 : 서태수, 이재훈, 임승태, 이득찬, 한준희, 홍민, 최다혜, 이선엽, 이재학, 유근형

초록

Background: Given the reported pharmacological effects of rutin from asparagus stems and roots, here, we assessed the anti-hangover and anti-gout effects of asparagus stem and root extracts.
Methods and Results: We found that rutin amount in ethanol extracts of asparagus stems was 10.15 ㎎/g, and in hydrothermal extracts of asparagus roots it was 3.28 ㎎/g. Alcohol dehydroge nase and aldehyde dehydrogenase activities in asparagus-stem extracts were 80% and 40% of those in the control group, respectively. Following hangover induction in rats using alcohol, an injection of 400 ㎎/㎏ body weight (BW) of the extract significantly reduced the blood alcohol concentra tion compared to that of the control group. Additionally, blood gamma-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) con centrations measured 5 h after alcohol administration revealed that treatment with 400 ㎎/㎏ BW of extract significantly reduced GGT and GOT concentrations compared to the control group, whereas changes in GPT were not significant. Moreover, xanthine oxidase activity after treatment with hydrothermal extracts of asparagus roots was 44.01 ± 0.32%, showing 53.3% inhibition com pared to the positive control (allopurinol; 82.50 ± 4.98%). To assess the anti-gout effect of hydro thermal extracts of asparagus roots, we induced gout in rats by intraperitoneal injection of potassium oxonate and measured blood uric acid, creatinine, and blood urea nitrogen concentra tions at 3 h post-administration of the extract. The results showed a significant reduction in creati nine and uric acid levels in the treated group compared to the control.
Conclusions: These findings demonstrated the potential of asparagus stem and root extracts as functional ingredients.

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