피부각질형성세포에서 다양한 베리류의 피부노화개선 효과 비교 (The Anti-aging Effects of Various Berries in the Human Skin Keratinocyte (HaCaT) Cells)

서지정보

· 발행기관 : 한국식품과학회
· 수록지 정보 : 한국식품과학회지 / 46권 / 2호 / 198 ~ 204페이지
· 저자명 : 이수정, 최혜란, 이진철, 박희전, 이희권, 정종태, 이태범

초록

Ultraviolet B (UV-B) irradiation is a negative factor that induces skin damage, inflammation, and aging. UVBirradiation induces the inflammatory response through interleukin (IL)-6 and IL-8 expression in keratinocytes. Inaddition, it induces the production of reactive oxygen species (ROS) and the activation of matrix metalloproteinase-1(MMP-1), which plays an important role in collagen 1 degradation in the extracellular matrix. We investigated the antiagingeffects of five kinds of berry in human skin keratinocyte (HaCaT) cells using juice of black raspberry (Rubusoccidentalis), blueberry wild (Vacciniun angustifolium) and cultivar (Vacciniun corymbosum), black chokeberry (Aroniamelanocarpa (Michx.) Elliott), and mulberry (Morus abla). HaCaT cells irradiated with UV-B exhibited increased ROSgeneration, as well as IL-6, IL-8, and MMP-1 gene expression, when compared to the control cells that were not irradiatedwith UV-B. However, pre-treatment of berry juice before UV-B irradiation significantly down-regulated the UV-B-inducedROS generation and inflammatory cytokine and MMP-1 expression. The results suggest that all berries have anti-agingeffects including lowering inflammatory cytokine levels, ROS generation, and MMP-1 expression in HaCaT cells duringUV-B irradiation.

영어초록

Ultraviolet B (UV-B) irradiation is a negative factor that induces skin damage, inflammation, and aging. UVBirradiation induces the inflammatory response through interleukin (IL)-6 and IL-8 expression in keratinocytes. Inaddition, it induces the production of reactive oxygen species (ROS) and the activation of matrix metalloproteinase-1(MMP-1), which plays an important role in collagen 1 degradation in the extracellular matrix. We investigated the antiagingeffects of five kinds of berry in human skin keratinocyte (HaCaT) cells using juice of black raspberry (Rubusoccidentalis), blueberry wild (Vacciniun angustifolium) and cultivar (Vacciniun corymbosum), black chokeberry (Aroniamelanocarpa (Michx.) Elliott), and mulberry (Morus abla). HaCaT cells irradiated with UV-B exhibited increased ROSgeneration, as well as IL-6, IL-8, and MMP-1 gene expression, when compared to the control cells that were not irradiatedwith UV-B. However, pre-treatment of berry juice before UV-B irradiation significantly down-regulated the UV-B-inducedROS generation and inflammatory cytokine and MMP-1 expression. The results suggest that all berries have anti-agingeffects including lowering inflammatory cytokine levels, ROS generation, and MMP-1 expression in HaCaT cells duringUV-B irradiation.

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