창상치료용 오적골 혼합 하이드로콜로이드 막의 개발 및 효능 (Development and Efficacy Study of Hydrocolloid Membrane Containing Cuttlefish Bone for Wound Treatment)

서지정보

· 발행기관 : 한국생체재료학회
· 수록지 정보 : 생체재료학회지 / 17권 / 2호 / 73 ~ 81페이지
· 저자명 : 곽문화, 김지은, 이영주, 송성화, 고준, 이재원, 인정훈, 김은정, 정영진, 윤영현, 황대연

초록

Cuttlefish bone (CB) which is the hard tissue acting as a floating tank in cuttlefish has application to various fields including a bone substitute, biosensor matrix substrate, antioxidant and scaffold for tissue engineering. Aim of this study was whether hydrocolloid membrane containing cuttlefish bone (HMCB) could contribute to the improvement of the wound repair process in skin of SD rats. To achieve this, HMCB was developed using the mixture dispersed CB powder in hydrocolloid, and an alteration on the histology and physiology of wound skin were observed in SD rats after the treatment of HMCB for 10 days. The dispersion solution of cuttlefish bone showed low salt concentration and electric resistance, high electrical conductivity, and medium pH level. Also, two types of HMCB (HMCB15 and HMCB30) were successfully prepared with adding two different concentrations of cuttlefish bone into hydrocolloid mixture. A significant enhancement of absorptiveness was detected in HMCB30 compared with that of HM or HMCB15, although there was no difference between HM and HMCB15. Furthermore, in animals study, the diameter of wound area was significantly shorter in HMCB30 treated group than that in either HM or HMCB15 treated group. Especially, rats treated with HMCB30 displayed significant improvement in scar tissue reduction, epithelium regeneration, angiogenesis and extracellular matrix deposition in wound area, as compare with those of HM treated group. Therefore, these results indicated that HMCB could be applied therapeutically to aid wound healing in the skin of SD rats. Also, the presented data suggest that HMCB have great potential for the treatment of burn, diabetic and chronic wound defects.

영어초록

Cuttlefish bone (CB) which is the hard tissue acting as a floating tank in cuttlefish has application to various fields including a bone substitute, biosensor matrix substrate, antioxidant and scaffold for tissue engineering. Aim of this study was whether hydrocolloid membrane containing cuttlefish bone (HMCB) could contribute to the improvement of the wound repair process in skin of SD rats. To achieve this, HMCB was developed using the mixture dispersed CB powder in hydrocolloid, and an alteration on the histology and physiology of wound skin were observed in SD rats after the treatment of HMCB for 10 days. The dispersion solution of cuttlefish bone showed low salt concentration and electric resistance, high electrical conductivity, and medium pH level. Also, two types of HMCB (HMCB15 and HMCB30) were successfully prepared with adding two different concentrations of cuttlefish bone into hydrocolloid mixture. A significant enhancement of absorptiveness was detected in HMCB30 compared with that of HM or HMCB15, although there was no difference between HM and HMCB15. Furthermore, in animals study, the diameter of wound area was significantly shorter in HMCB30 treated group than that in either HM or HMCB15 treated group. Especially, rats treated with HMCB30 displayed significant improvement in scar tissue reduction, epithelium regeneration, angiogenesis and extracellular matrix deposition in wound area, as compare with those of HM treated group. Therefore, these results indicated that HMCB could be applied therapeutically to aid wound healing in the skin of SD rats. Also, the presented data suggest that HMCB have great potential for the treatment of burn, diabetic and chronic wound defects.

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