두경부 편평세포암에서 COX-2, MMP-9, p53 및 VEGF 동시발현성에 대한 면역조직화학적 연구 (Combined Expression of COX-2, MMP-9, p53 and VEGF in Squamous Cell Carcinoma of the Head and Neck)

서지정보

· 발행기관 : 대한이비인후과학회
· 수록지 정보 : 대한이비인후-두경부외과학회지 / 51권 / 11호 / 1036 ~ 1042페이지
· 저자명 : 황준연, 이규호, 유재형, 이세영, 양훈식

초록

COX-2, MMP-9, p53 and VEGF play an important role in the invasion and metastasis of tumor,
and their roles are known to interact with each other. In this study, we investigated the relationship between gene protein
expression and clinical parameters including synchronicity to the progression and metastasis in the head and neck squamous cell
carcinoma. Subjects and Method：Tissue samples and clinical data were obtained from 69 head and neck squamous cell
carcinoma patients who underwent surgery as initial treatment except nasopharngeal carcinoma from January 1999 to December
2003. Their primary sites were: oral cavity (12), pharynx (18) and larynx (39). Immunohistochemical stain was performed to
evaluate the expression rate of COX-2, MMP-9, p53, VEGF and then expression patterns and clinical data were analysed.
Results：The expressions of COX-2, MMP-9, p53 and VEGF immunoreactivities were observed as 57.9%, 49.3%. 60.9% and
44.9%, respectively. MMP-9 was significantly correlated with T-stage (p=0.021) and COX-2 and p53 levels were significantly
correlated with lymph node metastasis (p=0.019 and p=0.001, respectively). Multiple (2 kinds, 3 kinds, 4 kinds) expressions
of gene protein were found in 31.9%, 21.7%, and 10.2%, respectively. There was a significant statistical difference between the
multiple expression of gene protein to lymph node metastasis and a single expression of gene protein (p=0.030). Conclusion：
These data suggested that COX-2, MMP-9 and p53 expression may play a role of tumor progression and metastasis in the head
and neck squamous cell carcinoma. We may conclude that the synchronous gene protein expression was superior to the single
gene expression in estimating progression and metastasis of the head and neck squamous cell carcinoma. (Korean J Otorhinolaryngol-
Head Neck Surg 2008;51:1036-42)

영어초록

COX-2, MMP-9, p53 and VEGF play an important role in the invasion and metastasis of tumor,
and their roles are known to interact with each other. In this study, we investigated the relationship between gene protein
expression and clinical parameters including synchronicity to the progression and metastasis in the head and neck squamous cell
carcinoma. Subjects and Method：Tissue samples and clinical data were obtained from 69 head and neck squamous cell
carcinoma patients who underwent surgery as initial treatment except nasopharngeal carcinoma from January 1999 to December
2003. Their primary sites were: oral cavity (12), pharynx (18) and larynx (39). Immunohistochemical stain was performed to
evaluate the expression rate of COX-2, MMP-9, p53, VEGF and then expression patterns and clinical data were analysed.
Results：The expressions of COX-2, MMP-9, p53 and VEGF immunoreactivities were observed as 57.9%, 49.3%. 60.9% and
44.9%, respectively. MMP-9 was significantly correlated with T-stage (p=0.021) and COX-2 and p53 levels were significantly
correlated with lymph node metastasis (p=0.019 and p=0.001, respectively). Multiple (2 kinds, 3 kinds, 4 kinds) expressions
of gene protein were found in 31.9%, 21.7%, and 10.2%, respectively. There was a significant statistical difference between the
multiple expression of gene protein to lymph node metastasis and a single expression of gene protein (p=0.030). Conclusion：
These data suggested that COX-2, MMP-9 and p53 expression may play a role of tumor progression and metastasis in the head
and neck squamous cell carcinoma. We may conclude that the synchronous gene protein expression was superior to the single
gene expression in estimating progression and metastasis of the head and neck squamous cell carcinoma. (Korean J Otorhinolaryngol-
Head Neck Surg 2008;51:1036-42)

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