섬망 치료에 있어서 지프라시돈(Ziprasidone)과 리스페리돈(Risperidone)의 효과 비교 (Comparison between Effectiveness of Ziprasidone and Risperidone for Treatment of Delirium in Hospitalized Patients)

서지정보

· 발행기관 : 대한생물치료정신의학회
· 수록지 정보 : 생물치료정신의학 / 15권 / 1호 / 64 ~ 71페이지
· 저자명 : 김경식, 정성원

초록

Objectives：It has been shown that risperidone, an atypical antipsychotics, has effectiveness for treatment of
delirium as good as haloperidol and has less side effects than haloperidol. Ziprasidone also has less extrapyramidal
and anticholinergic side effects, but there has been little information published on ziprasidone for the treatment of
patients with delirium. Therefore, this study investigated whether ziprasidone had effectiveness for treatment of delirium
and whether there was a differential effect between risperidone and ziprasidone.
Methods：Sixteen patients with delirium were enrolled in this study. All subjects(16 patients) were randomized to
receive either risperidone(7 patients) or ziprasidone(9 patients) with fixed dose at the first day of treatment. Risperidone
group was given 1mg and ziprasidone group was given 20mg at the first day of treatment in the night. Then,
all subjects received either medications with flexible doses according to judgement on clinical status of patients.
The effectiveness was evaluated using Clinical Global Impression-Severity(CGI-S), Korean version of Delirium Rating
Scale(K-DRS), Korean Mini Mental Status Examination(K-MMSE), and Korean version of Delirium Rating Scale-
Revised-98. The side effects was evaluated using Extrapyramidal Symptom Rating Scale(ESRS) which was
administered by a trained psychiatrist.
Results：There was no significant difference between both groups in the baseline K-DRS, K-DRS-R-98, KMMSE
and CGI scores. At the seventh day of the treatment, K-DRS, K-DRS-R-98 and CGI scores were significantly
decreased from the baseline in the ziprasidone treatment group, but not in risperidone treatment group.
Conclusion：These results suggest that ziprasidone appears to be more effective than risperidone for treatment
of delirium.

영어초록

Objectives：It has been shown that risperidone, an atypical antipsychotics, has effectiveness for treatment of
delirium as good as haloperidol and has less side effects than haloperidol. Ziprasidone also has less extrapyramidal
and anticholinergic side effects, but there has been little information published on ziprasidone for the treatment of
patients with delirium. Therefore, this study investigated whether ziprasidone had effectiveness for treatment of delirium
and whether there was a differential effect between risperidone and ziprasidone.
Methods：Sixteen patients with delirium were enrolled in this study. All subjects(16 patients) were randomized to
receive either risperidone(7 patients) or ziprasidone(9 patients) with fixed dose at the first day of treatment. Risperidone
group was given 1mg and ziprasidone group was given 20mg at the first day of treatment in the night. Then,
all subjects received either medications with flexible doses according to judgement on clinical status of patients.
The effectiveness was evaluated using Clinical Global Impression-Severity(CGI-S), Korean version of Delirium Rating
Scale(K-DRS), Korean Mini Mental Status Examination(K-MMSE), and Korean version of Delirium Rating Scale-
Revised-98. The side effects was evaluated using Extrapyramidal Symptom Rating Scale(ESRS) which was
administered by a trained psychiatrist.
Results：There was no significant difference between both groups in the baseline K-DRS, K-DRS-R-98, KMMSE
and CGI scores. At the seventh day of the treatment, K-DRS, K-DRS-R-98 and CGI scores were significantly
decreased from the baseline in the ziprasidone treatment group, but not in risperidone treatment group.
Conclusion：These results suggest that ziprasidone appears to be more effective than risperidone for treatment
of delirium.

참고자료

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