굼벵이 유래 밀리타리스 동충하초 열수추출물의 간기능개선 효과 및 단회독성 평가 (Hepatic Protective Effect and Single-dose Toxicity Study of Water Extract of Cordyceps militaris Grown upon Protaetia dreujtarsis)

서지정보

· 발행기관 : 한국식품과학회
· 수록지 정보 : 한국식품과학회지 / 40권 / 1호 / 106 ~ 110페이지
· 저자명 : 조월순, 남병혁, 오수정, 최유진, 강은영, 홍숙희, 이상호, 정민호

초록

This study was designed to evaluate the single dose toxicity and the protective effect of water extract of
Cordyceps militaris grown upon Protaetia dreujtarsis (CMPD extract) on liver damage on carbon tetrachloride (CCl₄)-
induced acute hepatotoxicity in Sprague-Dawley (SD) rats. The CMPD extract was once administered orally to both sexes
of rats at dose of 2,000, 1,000 and 500 mg/kg body weight, the recommended maximum limit dose for acute toxicity.
Neither significant toxic signs nor death was observed during the observation period. These results indicate that LD50 (lethal
dose of 50%) of CMPD extract is greater than 2,000 mg/kg body weight in SD rats. To investigate also the effect of
hepatoprotection of CMPD extract, SD rats were orally treated with CMPD extract (50, 25 and 12.5 mg/kg body weight)
or silymarin (25 mg/kg body weight) before and after administration of CCl₄ (2 mL/kg body weight, 20% CCl₄ in olive
oil). Treatment with CMPD extract or silymarin could decrease the GPT (glutamic-pyruvic transaminase) and GOT
(glutamic-oxaloacetic transaminase) levels in serum when compared with CCl₄-treated group. Therefore, the results of this study show that CMPD extract can be proposed to protect the liver against CCl₄-induced hepatic damage in rats.

영어초록

This study was designed to evaluate the single dose toxicity and the protective effect of water extract of
Cordyceps militaris grown upon Protaetia dreujtarsis (CMPD extract) on liver damage on carbon tetrachloride (CCl₄)-
induced acute hepatotoxicity in Sprague-Dawley (SD) rats. The CMPD extract was once administered orally to both sexes
of rats at dose of 2,000, 1,000 and 500 mg/kg body weight, the recommended maximum limit dose for acute toxicity.
Neither significant toxic signs nor death was observed during the observation period. These results indicate that LD50 (lethal
dose of 50%) of CMPD extract is greater than 2,000 mg/kg body weight in SD rats. To investigate also the effect of
hepatoprotection of CMPD extract, SD rats were orally treated with CMPD extract (50, 25 and 12.5 mg/kg body weight)
or silymarin (25 mg/kg body weight) before and after administration of CCl₄ (2 mL/kg body weight, 20% CCl₄ in olive
oil). Treatment with CMPD extract or silymarin could decrease the GPT (glutamic-pyruvic transaminase) and GOT
(glutamic-oxaloacetic transaminase) levels in serum when compared with CCl₄-treated group. Therefore, the results of this study show that CMPD extract can be proposed to protect the liver against CCl₄-induced hepatic damage in rats.

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