골다공증 유도 백서에서 임플란트 삽입후 칼슘과 비타민 D의 섭취가 골조직에서 혈관내피세포성장인자 수용체 발현에 미치는 영향 (The Effect of Intake of Calcium and Vitamin D on the Expression of Vascular Endothelial Growth Factor Receptors (VEGFR) in Bone Tissue Around Implant in Osteoporosis Induced-Rats)

서지정보

· 발행기관 : 한국조직공학과 재생의학회
· 수록지 정보 : 조직공학과 재생의학 / 8권 / 4호 / 73 ~ 79페이지
· 저자명 : 김호철, 권택균, 이재열, 송재민, 정인교, 김규천, 신상훈

초록

Angiogenesis is closely assocatied with bone formation and osteoporosis is risk factor of success of implant. Recently reported, uptake of calcium and Vitamin D improve bone healing process in osteoporosis. Vascular endothelial growth factor also interact bone formation through modulation of angiogenesis. The purpose of this study was to evaluate the interaction between vascular endothelial growth factor (VEGF) and calcium with vitamin D in bone tissue around implant in osteoporosis induced rats by measuring the expression of vascular endothelial grawth factor receptors (VEGFR). Titanium screw type implants were placed into tibias of ovariectomized. The rats were sacrificed at different time interval (1,2 and 4 weeks after implantaion) for immunohistochemistry with antibody for receptor of vascular endothelial growing factor 1, 2 and 3. In this study we observed 3 type vascular endothelial growth factor (VEGFR1-3). Receptor of vascular endothelial growth factor 3 (VEGFR-3) was increased by calcium and vitamin D in bone formation process but others (receptor of vascular endothelial growth factor 1 and 2)were not shown significant difference. This study, with previously published work, shows that VEGF interact with calcium and vitamin D and especially VEGFR-3 was incresed in early stage.

영어초록

Angiogenesis is closely assocatied with bone formation and osteoporosis is risk factor of success of implant. Recently reported, uptake of calcium and Vitamin D improve bone healing process in osteoporosis. Vascular endothelial growth factor also interact bone formation through modulation of angiogenesis. The purpose of this study was to evaluate the interaction between vascular endothelial growth factor (VEGF) and calcium with vitamin D in bone tissue around implant in osteoporosis induced rats by measuring the expression of vascular endothelial grawth factor receptors (VEGFR). Titanium screw type implants were placed into tibias of ovariectomized. The rats were sacrificed at different time interval (1,2 and 4 weeks after implantaion) for immunohistochemistry with antibody for receptor of vascular endothelial growing factor 1, 2 and 3. In this study we observed 3 type vascular endothelial growth factor (VEGFR1-3). Receptor of vascular endothelial growth factor 3 (VEGFR-3) was increased by calcium and vitamin D in bone formation process but others (receptor of vascular endothelial growth factor 1 and 2)were not shown significant difference. This study, with previously published work, shows that VEGF interact with calcium and vitamin D and especially VEGFR-3 was incresed in early stage.

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