폐경 후 호르몬 요법시 초기 생화학적 골표지자와 골밀도 변화와의 상관관계 (The Relationship Between Initial Biochemical Bone Markers and Change of Bone Mineral Density in Post Menopausal Women with Hormone Therapy)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 22권 / 1호 / 212 ~ 219페이지
· 저자명 : 조지희, 공은희, 최영식, 김양수, 김흥열, 어완규, 홍기연

초록

Background : This study was aimed to estimate the relationship between bone mineral density after hormone therapy (HT) for one year and short-term changes of bone markers in postmenopausal women.
Methods: Biochemical markers of serum osteocalcin (OC) and urine deoxypyridinoline (Dpd) at 3 months and lumbar bone mineral density (BMD) were measured at 1 year in 80 operated postmenopausal women(PMW) taking HT.
Results : Serum OC and urine Dpd decreased from 10.85% at baseline to 7.87% at 3 months and BMD increased 2.2% after 1 year of treatment. 56 (80%) among 70 with decreased OC revealed increasement of BMD, while 50 (78.1%) among 64 PMW with decreased urine Dpd showed increasement of BMD.
Serum OC of bone gainers was lower than of bone losers (10.18% vs 14.01%) and urine Dpd also lower than that of bone losers (7.29% vs 10.6%). No correlations between biochemical markers such as, serum OC (r=-0.034) and urine Dpd (r=-0.031that ) checked at 3 months and BMD at 1 year were seen in postmenopausal women.
Conclusion: Short-term changes of bone markers did not precisely predict the long-term changes of BMD in postmenopausal women.

영어초록

Background : This study was aimed to estimate the relationship between bone mineral density after hormone therapy (HT) for one year and short-term changes of bone markers in postmenopausal women.
Methods: Biochemical markers of serum osteocalcin (OC) and urine deoxypyridinoline (Dpd) at 3 months and lumbar bone mineral density (BMD) were measured at 1 year in 80 operated postmenopausal women(PMW) taking HT.
Results : Serum OC and urine Dpd decreased from 10.85% at baseline to 7.87% at 3 months and BMD increased 2.2% after 1 year of treatment. 56 (80%) among 70 with decreased OC revealed increasement of BMD, while 50 (78.1%) among 64 PMW with decreased urine Dpd showed increasement of BMD.
Serum OC of bone gainers was lower than of bone losers (10.18% vs 14.01%) and urine Dpd also lower than that of bone losers (7.29% vs 10.6%). No correlations between biochemical markers such as, serum OC (r=-0.034) and urine Dpd (r=-0.031that ) checked at 3 months and BMD at 1 year were seen in postmenopausal women.
Conclusion: Short-term changes of bone markers did not precisely predict the long-term changes of BMD in postmenopausal women.

참고자료

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