Pluronic F127/PVA 혼합겔의 수술 후 조직유착 방지 효과 (Prevention of Postsurgical Tissue Adhesion by Pluronic F127/Polyvinyl Alcohol Complex Gel)

서지정보

· 발행기관 : 한국생체재료학회
· 수록지 정보 : 생체재료학회지 / 12권 / 4호 / 135 ~ 140페이지
· 저자명 : 임천수, 오세행, 이진호

초록

Several investigators have evaluated the use of aqueous Pluronic F127 gel as a tissue adhesion barrier because it is
biocompatible and bioresorbable, and shows a lower critical solution temperature (LCST; i. e., reverse sol–gel transition
temperature) below the human physiological temperature and thus exists to a gel state in the body at 37°C. However,
it has low efficacy due to fast absorption of the gel dissolved by dilution from the body fluid before wound healing.
In this study, we prepared Pluronic F127/polyvinyl alcohol (PVA) complex gel created by hydrogen bonding which can
improve the stability of the Pluronic F127 gel in the body. The viscosity and water stability of the complex gels with
different Pluronic F127/PVA ratio were evaluated to determine the optimum complexation condition (in vitro). The
anti-tissue adhesion potential of the complex gel was also evaluated by in vivo animal study using a rat model. From
the animal study, it was observed that the Pluronic F127/PVA complex gel was highly effective for the prevention of
peritoneal tissue adhesion and showed no adverse tissue reaction, and thus can be a good candidate material as a
coatable or injectable tissue adhesion barrier gel.

영어초록

Several investigators have evaluated the use of aqueous Pluronic F127 gel as a tissue adhesion barrier because it is
biocompatible and bioresorbable, and shows a lower critical solution temperature (LCST; i. e., reverse sol–gel transition
temperature) below the human physiological temperature and thus exists to a gel state in the body at 37°C. However,
it has low efficacy due to fast absorption of the gel dissolved by dilution from the body fluid before wound healing.
In this study, we prepared Pluronic F127/polyvinyl alcohol (PVA) complex gel created by hydrogen bonding which can
improve the stability of the Pluronic F127 gel in the body. The viscosity and water stability of the complex gels with
different Pluronic F127/PVA ratio were evaluated to determine the optimum complexation condition (in vitro). The
anti-tissue adhesion potential of the complex gel was also evaluated by in vivo animal study using a rat model. From
the animal study, it was observed that the Pluronic F127/PVA complex gel was highly effective for the prevention of
peritoneal tissue adhesion and showed no adverse tissue reaction, and thus can be a good candidate material as a
coatable or injectable tissue adhesion barrier gel.

참고자료

· 없음