Ameliorating Effect of Selenium against Arsenic Induced Male Reproductive Toxicity in Rats

서지정보

· 발행기관 : 한국동물번식학회
· 수록지 정보 : Reproductive & developmental biology / 38권 / 3호
· 저자명 : Abdulkadhar Mohamed Jalaludeen, Ran Lee, Won Young Lee, Dong Hoon Kim, Hyuk Song

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Chemicals and Reagents
Animals
Preparation and Administration of Arsenic and Selenium
Experimental Time Line
Measurement of Sperm Motility, Velocity, Movements and Morphology
Histopathological Examination of Testis
Statistical Analysis
RESULTS
Effect of Selenium and Arsenic on Testis Weight and Sperm Motility
Effect of Selenium and Arsenic on Detailed Motion Characteristics
Changes in Motion and Morphological Index
Effect of Selenium and Arsenic on ALH and BCF
Effect of Selenium and Arsenic on Histopathological Studies
DISCUSSION
CONCLUSION
ACKNOWLEDGMENTS
REFERENCES

undefined

영어초록

Oral exposure of humans by excess amounts of arsenic may cause disturbances of the reproductive system. In the present study, such exposure was modelled in rats, with the support of sperm principal parameters and histopa-thological observations. Male Sprague–Dawley rats were randomly divided into three groups where the group I was served as a normal control, group II was received sodium meta-arsenite as arsenic (10 mg/kg b.w/day) and a combi-nation of sodium meta- arsenite and sodium selenite (3 mg/kg b.w/day) in group III. After 6 weeks, there was no significant change in testis weight and in total motility of all the three experimental groups, whereas, rapid moving spermatozoa, moderately moving spermatozoa and slow moving spermatozoa were significantly decreased in arsenic treated rats as compared to control rats. The other sperm principal parameters like progressiveness, average path velocity, straightness linear velocity (VSL), curvilinear velocity (VCL), straightness, linearity sperm head elongation ratio, area, linearity amplitude of lateral head department (ALH) and beat cross frequency (BCF) were found to be reduced in arsenic intoxicated rats. These results are not correlated with the histological studies. On oral admini-stration of selenium ameliorated the adverse effects of arsenic as compared to arsenic alone treated rats. Our findings clearly demonstrate that administration of selenium could prevent some of the deleterious effects of arsenic in the testis.

참고자료

· 없음