난소 적출로 유발된 골다공증 흰쥐에서 콩나물 추출 이소플라본이 골대사 관련 호르몬 및 조직학적 변화에 미치는 영향

서지정보

· 발행기관 : 한국교육원리학회
· 수록지 정보 : 교육원리연구 / 2권 / 1호
· 저자명 : 김계엽, 심기철, 김기도, 조건식, 김경윤

목차

서 론
재료 및 방법
결 과
고 찰
결 론
참고문헌

초록

영어초록

The aim of this study was to investigate the effects of level of isoflavones supplementation on bone related hormones
and histological changes of femur in osteoporosis rats. The effects of the level of isoflavones supplementation on
calcium; alkaline phosphate (ALP), GOT, GPT blood level; length, circumference, and weight of femur; estradiol level as one
of the bone related hormones; and the histological finding of femur were inspected in this study. This study classified 40
10-weeks-old male Sprague Dawley rats which have osteoporosis caused by ovariectomy into four groups of 10 rats. The
rats were medicated with isoflavone. Group I was a non-treatment after osteoporosis (control); Group II was a low-dose
isoflavone (20 mg/kg) feeding group after osteoporosis; Group III was a middle-dose isoflavone (40 mg/kg) feeding group
after osteoporosis; Group IV was a high-dose isoflavone (80 mg/kg) feeding group after osteoporosis. In respect to the length,
circumference, weight of femur, there was no statistically significant difference between groups II, III, IV compared to group I
(p>0.05). In the ALP, GOT, GPT level, there was a statistically significant difference between the group II, III, IV compared to
group I (p<0.01). In calcium levels there was a statistically significant difference between the group III, IV compared to group
I, II. But, that is no significant in group I and group II. In the estradiol level, there was a statistically significant difference between
the group II, III, IV compared to group I (p<0.01). In respect to histological findings, group II, III, IV showed a mild femur disruption
and lytic change on femur section. The results above suggests that isoflavone medication is effective in the prevention
and treatment of osteoporosis.

참고자료

· 없음