서울여자대학교 유기화학실험 Aldol condensation 결과 레포트

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1. Aldol condensation

유기화학실험 Report 12에서는 benzaldehyde와 acetone의 aldol condensation 반응을 수행하였다. 이 반응은 두 개의 탄소-탄소 결합을 형성하는 중요한 유기화학 반응이다. 반응 과정에서 중간체인 benzylideneacetone이 생성되고, 최종적으로 trans, trans-isomer의 dibenzylideneacetone이 생성된다. 이 반응은 모든 단계가 평형 반응이어서 100% 수득률을 얻기 어려우며, 중간체와 부산물이 관찰될 수 있다. TLC 분석 결과, 예상대로 dibenzylideneacetone이 major product로 확인되었고, benzylideneacetone이 minor product로 관찰되었다.

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1. Aldol condensation

Aldol condensation is an important organic reaction that involves the formation of a new carbon-carbon bond through the reaction of an enolate ion with a carbonyl compound. This reaction is widely used in the synthesis of various organic compounds, particularly in the pharmaceutical and fine chemical industries. The reaction proceeds through a nucleophilic addition of the enolate ion to the carbonyl group, followed by an elimination step to form an α,β-unsaturated carbonyl compound. The aldol condensation reaction is highly versatile and can be used to construct a wide range of complex organic molecules, making it a valuable tool in organic synthesis. However, the reaction can be challenging to control, as it can lead to the formation of multiple products, depending on the specific reaction conditions and the nature of the starting materials. Overall, the aldol condensation is a powerful and widely used reaction in organic chemistry, with numerous applications in the synthesis of important organic compounds.