INTERLEUKIN-2 (영문PPT)
- 최초 등록일
- 2013.07.31
- 최종 저작일
- 2012.03
- 27페이지/
MS 파워포인트
- 가격 1,500원
목차
1. OVERVIEW - Cytokine
2. INTERLEUKIN-2 - Overview of IL
3. INTERLEUKIN-2 - Structure of IL-2
4. The IL-2/IL-2 receptor - Overview of IL-2 receptor
5. The mechanism of IL-2 activation
6. The function of IL-2 - Overview of interleukin-2 function
7. Regulatory sites and corresponding transcription factors
8. Cells and tissues that express the gene
9. Adoptive Immunotherapy by IL-2
10. References
본문내용
* Overview of IL-2
- In Adoptive Immunotherapy IL-2 is administered
High-dose bolus recombinant IL-2 (600,000 to 720,000 IU/kg IV)
- Acts as a potent immunomodulator and antitumor element
- Positive results have led approval of high dose IL-2 for patients with metastatic melanoma and Renal cell carcinoma.
- Extensive multiorgan toxicity may occur
<중 략>
* Overview of IL-2 receptor
- Interleukin (IL)-2 is a small (15-kDa) -helical cytokine produced primarily by recently activated T cells, which induce its biological response after binding to a high-affinity receptor.
- The IL-2 receptor (IL-2R) is comprised of three subunits, an α-chain that functions only for IL-2 binding, and the and subunits, which function to augment ligand binding and induce cellular signaling.
참고 자료
S.L. Gaffen, K.D. Liu / Cytokine 28 (2004) 109e123
Immunity 33, August 27, 2010
Brain Research Reviews 21 (1996) 246-284
Immunological Reviews 241/2011
Cytokine and Growth Factor Reviews 13 (2002) 27-40
Journal of Leukocyte Biology Volume 74, December 2003
Immunity 32, January 29, 2010
Cell Cycle 7:4, 458-462; 15 February 2008
Immunology and Cell Biology (2011) 89, 27-32
J Immunol 2004;172;3983-3988
Seminars in Immunology 21 (2009) 363-371
