Syphilis (매독)

소개

매독에 관한 레포트 자료 입니다.
매독에 대해서 발표를 준비하거나 공부를 하시는 분께 도움이 되리라 생각합니다.

목차

없음

본문내용

Definition
Chronic systemic infection caused by Treponema pallidum
Sexually transmitted disease
Incubation period averaging 2?6 weeks
→Primary lesion appears (chancre, regional lymphadenopathy 관련)
→Secondary stage (syphilid, generalized mucocutaneous lesions, lymphadenopathy)
→Latent syphilis
→Tertiary stage (치료하지 않은 환자의 1/3에서)

* Etiology
T. pallidum subspecies (distinguished primarily by the clinical syndromes they produce)
- pallidum : causes venereal syphilis
pertenue : causes yaws
endemicum : causes endemic syphilis or bejel
carateum : causes pinta
현재는 PCR을 통해서 각각을 구별할 수 있다. 그 외 Treponema subspecies들은 인간의 입, 위장관계, 생식기에서 발견된다.

T. pallidum : ttrilaminar cytoplasmic membrane에 싸인 가는 spiral organism
delicate peptidoglycan layer, lipid-rich outer membrane, Endoflagella 등으로 구성
in vitro에서 배양 불가능하여 1998년부터 균에 대한 정보가 알려지기 시작

참고자료

· Centers for Disease Control and Prevention: 2006 Sexually transmitted diseases treatment guidelines. MMWR 55:22, 2006
· Centurion-Lara A et al: Gene conversion: A mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol 52:1579, 2004 [PMID: 15186410]
· Grassly NC et al: Host immunity and synchronized epidemics of syphilis across the United States. Nature 433:417, 2005 [PMID: 15674292]
· Lukehart SA et al: Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med 351:154, 2004 [PMID: 15247355]
· Marra CM et al: Cerebrospinal fluid abnormalities in patients with syphilis: Association with clinical and laboratory features. J Infect Dis 189:369, 2004 [PMID: 14745693]
· ??? et al: Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: Does HIV status matter? Clin Infect Dis 38:1001, 2004
· Michelow IC et al: Central nervous system infection in congenital syphilis. N Engl J Med 346:1792, 2002 [PMID: 12050339]
· Peeling R et al: Avoiding HIV and dying of syphilis. Lancet 364:1561, 2004 [PMID: 15519615]
· Rolfs RT et al: A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N Engl J Med 337:307, 1997 [PMID: 9235493]