인공 망막 Artificial Retina

소개

인공 망막에 대한 전반적인 자료 보고 (영문)
Report for artificial retinal implant

목차

Artificial Retina
1. Introduce
2. Eye Anatomy and Physiology
3. Eye Disease
4. Retinal Prosthesis
5. Signal Transfer
6. Looking Forward
Reference

본문내용

Artificial retinal implant is a biomedical implant technology currently being developed by a number of private companies and research institutions worldwide. Artificial rentinal implant is meant to partially restore useful vision to people who have lost their sight for degenerative eye conditions such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) is a common cause of retinal blindness. In these disorders, despite a nearly total loss of photoreceptors, there is relative preservation of the inner retinal neurons. The technology consists of an array of electrodes implanted on the retina, a digital camera worn on the user`s body, and a transmitter and image processor that



Looking Forward
The feasibility of a retinal prosthesis to restore vision is currently under investigation in 5 clinical trials. The 16-electrode epiretinal implant from Second Sight Medical Products, Inc, Sylmar, California, has been implanted long-term in 6 subjects in the United States for more than 5 years, and this is the only study with subjects using the full system in their homes. Intelligent Medical Implants GmbH, Bonn, Germany, described 4 subjects with an implanted 49-electrode epiretinal array in a trial designed to last 18 months. The EPI RET3 25-electrode epiretinal array was implanted for 4 weeks in 6 blind subjects. A subretinal implant composed of a 1550-microphotodiode array and a 4x4-electrode array from Retina Implant AG, Reutlingen

참고자료

· 1. James D.Weiland, Wentai Liu and Mark S. Humayun Retinal Prosthesis. Annu. Rev. Biomed. Eng. 2005. 7:361-401.
· 2. Avi Caspi, Jessy D. Dorn, Kelly H. McClure, Mark S. Humayun, Robert J. Greenberg and Matthew J. McMahon Feasibility Study of a Retinal Prosthesis: Spatial Vision with a 16-Electrode implant. American Medical Association 2009. 127; 4:398-401.
· 3. Mokwa W. An Implantable Microsystem: As a Vision Prosthesis. Medical Device Technology 2007. 20-23.
· 4. Alan Y. Chow, Vincent Y. Chow, Kirk H. Packo, John S. Pollack, Gholam A. Peyman and Ronald Schuchard The Artificial Silicon Retina Microchip for the Treatment of Vision Loss From Retinitis Pigmentosa. American Medical Association 2004. 122; 460-469.
· 5. Viola M. V. and Patrinos A. A Neuroprosthesis for Restoring Sight. Acta neurochirurgica. 2007. 97; 481-486.
· 6. Ralf Hornig, Thomas Laube, PeterWalter, Michaela Velikay-Parel, Norbert Bornfeld, Matthias Feucht, Harun Akguel and Gernot R¨ossler A method and technical equipment for an acute human trial to evaluate retinal implant technology. JOURNAL OF NEURAL ENGINEERING. 2005. 2:S129-S134
· 7. Bron, A.J., Tripathi, R.C. and Tripathi, B.J. Wolff ’s Anatomy of the Eye and Orbit. London: Chapman & Hall. 8th ed. 1997.
· 8. Berson E.L. Retinitis pigmentosa. The Friedenwald Lecture. Invest. Ophthalmol. Vis. Sci.2003. 34; 5:1659–1676
· 9. Kim, S., Sadda S, Pearlman J, Humayun MS, de Juan E Jr, et al. Morphometric analysis of the macula in eyes with disciform age-related macular degeneration. Retina. 2002. 22; 4:471–477
· 10. Humayun MS,Weiland J, Fujii G, Greenberg RJ, Williamson R, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vis. Res. 2003. 43; 24:2573–2581
· 11. Zrenner, E., Stett, A., Weiss, S., Aramant, R.B., Guenther, E., et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors?. Vis. Res. 1999. 39:2555–2567
· 12. Liu, W., Vichienchom, K., Clements, M., DeMarco, S.C., Hughes, C., McGucken, E., Humayun, M.S., De Juan E., Weiland, J.D. and Greenberg, R. A neuro-stimulus chip with telemetry unit for a retinal prosthetic device. IEEE J Solid State Circuits. 2000. 35: 1487–1497