자가 말초혈액 조혈모세포 채집에 영향을 주는 관련요인 (Factors Influencing Peripheral Blood Stem Cell Collection)

서지정보

· 발행기관 : 대한종양간호학회
· 수록지 정보 : Asian Oncology Nursing / 8권 / 1호 / 1 ~ 7페이지
· 저자명 : 최용숙, 김광성, 김연순, 황미정, 조형숙, 김수미

초록

Purpose: Peripheral blood stem cell transplantation (PBSCT) has been widely used. The optimal time for collection is a critical
factor to obtain proper counts of CD34 cell by peripheral blood stem cell collection (PBSC). The purpose of this study
was to identify the factors influencing peripheral blood stem cell collection in order to figure out the more effective timing
for PBSC. Method: The subjects of this study were 189 patients undergoing 3 leukapheresis from January 28, 2005 to December
31, 2006. Group’s characteristics, checkup opinion of pre-peripheral blood on the day of harvest & outcome of PBSC
were analyzed and evaluated using SAS statistics program after grouping patients as below; group 1-CD34 cell counts <2
×106/kg (n=97); group 2-2×106/kg ≤CD34 cell counts <4×106/kg (n=26); group 3-CD34 cell counts ≥4×106/kg (n=63).
Results: Based on outcome of peripheral blood stem cell according to diagnosis, acute myelocytic leukemia (AML) was
65.5% at Group 1, Lymphoma was 21.7% at Group 2 and multiple myeloma (MM) was 70.8% at Group 3. There were
significant differences in CD34 cell counts according to diagnosis (p=0.00004). Type of cytokine mobilization according to
diagnosis, Lenograsim was using 62.5% of MM & 38.2% of AML and filgrastim is using 22.0% of AML only. Circular peripheral
blood CD34 cell counts prior to harvest was 258.1/ L at Group 3 which was much higher comparing to Group 1 (10.5/
L) and Group 2 (39.9/ L) (p<0.001). TNC counts of collected peripheral blood stem cell was 15.36×106/kg at Group 3
and it’s much higher than Group 2 (13.16×106/kg) and Group 1 (12.36×106/kg) (p=0.083). There was no significant difference
in MNC counts inbetween 3 groups. Conclusions: Circular peripheral blood CD34+ cell counts prior to harvest
was much higher at Group 3 than Group 1 and Group 2. Therefore, the number of CD34+ cells on the day of harvest can
be used as an accurate predictor for peripheral blood stem cell.

영어초록

Purpose: Peripheral blood stem cell transplantation (PBSCT) has been widely used. The optimal time for collection is a critical
factor to obtain proper counts of CD34 cell by peripheral blood stem cell collection (PBSC). The purpose of this study
was to identify the factors influencing peripheral blood stem cell collection in order to figure out the more effective timing
for PBSC. Method: The subjects of this study were 189 patients undergoing 3 leukapheresis from January 28, 2005 to December
31, 2006. Group’s characteristics, checkup opinion of pre-peripheral blood on the day of harvest & outcome of PBSC
were analyzed and evaluated using SAS statistics program after grouping patients as below; group 1-CD34 cell counts <2
×106/kg (n=97); group 2-2×106/kg ≤CD34 cell counts <4×106/kg (n=26); group 3-CD34 cell counts ≥4×106/kg (n=63).
Results: Based on outcome of peripheral blood stem cell according to diagnosis, acute myelocytic leukemia (AML) was
65.5% at Group 1, Lymphoma was 21.7% at Group 2 and multiple myeloma (MM) was 70.8% at Group 3. There were
significant differences in CD34 cell counts according to diagnosis (p=0.00004). Type of cytokine mobilization according to
diagnosis, Lenograsim was using 62.5% of MM & 38.2% of AML and filgrastim is using 22.0% of AML only. Circular peripheral
blood CD34 cell counts prior to harvest was 258.1/ L at Group 3 which was much higher comparing to Group 1 (10.5/
L) and Group 2 (39.9/ L) (p<0.001). TNC counts of collected peripheral blood stem cell was 15.36×106/kg at Group 3
and it’s much higher than Group 2 (13.16×106/kg) and Group 1 (12.36×106/kg) (p=0.083). There was no significant difference
in MNC counts inbetween 3 groups. Conclusions: Circular peripheral blood CD34+ cell counts prior to harvest
was much higher at Group 3 than Group 1 and Group 2. Therefore, the number of CD34+ cells on the day of harvest can
be used as an accurate predictor for peripheral blood stem cell.

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