기관지폐이형성증 환아에서 폐고혈압의 임상 경과 및 예후에 관한 분석: 단일 기관 연구 (Analysis of Clinical Course and the Prognosis of Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: A Single Center Study)

서지정보

· 발행기관 : 대한 소아알레르기 호흡기학회
· 수록지 정보 : Allergy Asthma & Respiratory Disease / 18권 / 3호 / 243 ~ 252페이지
· 저자명 : 김지현, 허준, 강이석, 이상일, 이흥재, 안강모

초록

Purpose:The aim of our study was to determine the clinical course and the prognosis of pulmonary hypertension (PHT) with bronchopulmonary dysplasia (BPD).
Methods:Two hundred forty infants who were admitted to the neonatal intensive care unit (NICU) of Samsung Medical Center from January 2002 to December 2006 and were diagnosed with BPD were enrolled in this study. We investigated their medical records retrospectively to investigate any difference between BPD with PHT　 group and 　BPD without PHT　 group in clinical characteristics, mortality and morbidity.
Results:Nineteen (7.9%) of the 240 patients with BPD developed PHT. The ratio of females to males was 2.8:1. The severity of BPD, the small birth weight for gestational age, the duration of mechanical ventilation and the maximal peak inspiratory pressure were significantly associated with the development of PHT. (P=0.000, P=0.007 and P=0.000, respectively) The mortality was higher in the BPD with PHT　group than in the　BPD without PHT　group. (P= 0.000) BPD with PHT　group required longer duration of oxygen therapy and had more rehospitalization for respiratory illness than the others. (P=0.014) More patients were admitted to the pediatric intensive care unit and received mechanical ventilation therapy in the　BPD with PHT　group. (P=0.001 and P=0.020, respectively)
Conclusions:PHT is one of the causes associated with high mortality and morbidity in BPD patients. Therefore, the physician should be alert to the development of PHT in premature infants with severe BPD, especially if the baby is female, less than 500 g of birth weight, small for gestational age, or supported by mechanical ventilation for a prolonged duration.

영어초록

Purpose:The aim of our study was to determine the clinical course and the prognosis of pulmonary hypertension (PHT) with bronchopulmonary dysplasia (BPD).
Methods:Two hundred forty infants who were admitted to the neonatal intensive care unit (NICU) of Samsung Medical Center from January 2002 to December 2006 and were diagnosed with BPD were enrolled in this study. We investigated their medical records retrospectively to investigate any difference between BPD with PHT　 group and 　BPD without PHT　 group in clinical characteristics, mortality and morbidity.
Results:Nineteen (7.9%) of the 240 patients with BPD developed PHT. The ratio of females to males was 2.8:1. The severity of BPD, the small birth weight for gestational age, the duration of mechanical ventilation and the maximal peak inspiratory pressure were significantly associated with the development of PHT. (P=0.000, P=0.007 and P=0.000, respectively) The mortality was higher in the BPD with PHT　group than in the　BPD without PHT　group. (P= 0.000) BPD with PHT　group required longer duration of oxygen therapy and had more rehospitalization for respiratory illness than the others. (P=0.014) More patients were admitted to the pediatric intensive care unit and received mechanical ventilation therapy in the　BPD with PHT　group. (P=0.001 and P=0.020, respectively)
Conclusions:PHT is one of the causes associated with high mortality and morbidity in BPD patients. Therefore, the physician should be alert to the development of PHT in premature infants with severe BPD, especially if the baby is female, less than 500 g of birth weight, small for gestational age, or supported by mechanical ventilation for a prolonged duration.

참고자료

· 없음