조짐편두통 환자와 무조짐편두통 환자 간의 평균혈소판용적 차이 (Difference in Mean Platelet Volume between Migraine Patients with and without Aura)

서지정보

· 발행기관 : 대한가정의학회
· 수록지 정보 : Korean Journal of Family Practice / 9권 / 4호 / 389 ~ 393페이지
· 저자명 : 반수지, 이준범, 진가헌, 김원용

초록

연구배경: 평균혈소판용적(mean platelet volume)은 혈소판이 활성화될 때 증가하며 편두통 환자에서 평균혈소판용적이 증가되는 것으로 알려져 있다. 본 연구는 조짐편두통 환자와 무조짐편두통 환자의 혈소판 수와 평균혈소판용적을 비교하고자 하였다.
방법: 2012년 1월부터 2017년 6월까지 홍익병원 외래로 내원하여 편두통을 진단받은 환자의 의무기록을 조사하였다. 편두통환자는 조짐편두통 환자와 무조짐편두통환자로 분류하였고, 두 군 간의 혈소판 수와 평균혈소판용적을 비교하였다. 또한 뇌경색, 심혈관 질환 등의 동반 유무도 조사하였다.
결과:조짐편두통환자 46명과무조짐편두통환자 77명이연구에포함되었다. 조짐편두통 환자군이 무조짐편두통 환자군보다 평균혈소판용적이 유의하게 컸고(migraine with aura [MA] 8.92±0.17 fL vs.
migraine without aura [MO] 6.32±0.28 fL, P=0.034), 뇌경색 및 심혈관질환의 동반 빈도가 높았다(ischemic stroke, MA 15.2% vs. MO 7.8%,P=0.027; cardiovascular disease, MA 10.9% vs. MO 6.5%, P=0.018).
결론: 평균혈소판용적은 무조짐편두통 환자보다 조짐편두통 환자에서 더 크다. 이는 두 질환 간에 병태 생리적인 차이와 관련이 있을것이다.

영어초록

Background: Mean platelet volume (MPV) increases when platelets are activated, and it is known to increase in migraine patients. The aim of this study is to investigate whether there is a difference in MPV or platelet count between migraine patients with (MA) and without aura (MO).
Methods: Migraine patients were recruited from the out-patient department of a hospital between January 2012 and June 2017. Patients were divided into MA and MO groups. Platelet count and MPV were compared between groups, and the frequency of comorbidities such as ischemic stroke and cardiovascular disease, was investigated in both groups.
Results: Of the 123 patients, 46 were classified as MA, and 77 were classified as MO. The MPV of the MA group was significantly higher than that of the MO group (8.92±0.17 fL, 6.32±0.28 fL, respectively) (P=0.034). However, platelet count showed no significant difference between groups. Cardiovascular disease and ischemic stroke incidences were significantly higher in the MA group than in the MO group (ischemic stroke: 15.2%, 7.8%, respectively, P=0.027; cardiovascular disease: 10.9%, 6.5%, respectively, P=0.018).
Conclusion: Mean platelet volume was significantly greater in the MA group than in the MO group. This may be related to the pathophysiological differences between the two conditions.

참고자료

· 없음