모르핀 내성에 대한 제 3군 Metabotropic 수용체의 역할 (The role of group III metabotropic receptors on opioid tolerance)

서지정보

· 발행기관 : 대한마취통증의학회
· 수록지 정보 : Anesthesia and Pain Medicine / 4권 / 2호 / 138 ~ 141페이지
· 저자명 : 윤명하, 이형곤, 김웅모, 조수영, 김여옥, 최금화

초록

Background: Prolonged exposure to morphine causes tolerance
to morphine-induced antinociception, yet the mechanisms of such
tolerance are not fully understood. Although group I and II metabolic
glutamate receptors (mGluRs) are involved in the modulation of
morphine tolerance, the role of the group III mGluRs has not been
determined. Therefore, we examined the effect of a group III
mGluRs agonist on the morphine tolerance in the spinal cord.
Methods: An intrathecal infusion of morphine (40 nmol/μl/h) for
5 days was done to examine the development of morphine tolerance
in male Sprague-Dawley rats. Noxious radiant heat was applied
to the hindpaw and we measured the thermal withdrawal latency.
To clarify the role of the group III mGluRs, an intrathecal group
III mGluRs agonist (ACPT-III) or saline was administered to the
morphine tolerant rats and we observed the change of the thermal
withdrawal latency at 15, 30, 60, 90 and 120 min after delivery of
ACPT-III.
Results: A continuous intrathecal infusion of morphine significantly
increased the thermal withdrawal latency, as compared with the
saline infused rats on day 1, with a decline on day 3 and the increase
of withdrawal latency totally disappeared on day 5 (tolerance).
Intrathecal ACPT-III increased the thermal withdrawal latency in the
morphine tolerance rats.
Conclusions: These results suggest that the group III mGluRs
may be involved in the suppression of tolerance to morphine-induced antinociception at the spinal level.

영어초록

Background: Prolonged exposure to morphine causes tolerance
to morphine-induced antinociception, yet the mechanisms of such
tolerance are not fully understood. Although group I and II metabolic
glutamate receptors (mGluRs) are involved in the modulation of
morphine tolerance, the role of the group III mGluRs has not been
determined. Therefore, we examined the effect of a group III
mGluRs agonist on the morphine tolerance in the spinal cord.
Methods: An intrathecal infusion of morphine (40 nmol/μl/h) for
5 days was done to examine the development of morphine tolerance
in male Sprague-Dawley rats. Noxious radiant heat was applied
to the hindpaw and we measured the thermal withdrawal latency.
To clarify the role of the group III mGluRs, an intrathecal group
III mGluRs agonist (ACPT-III) or saline was administered to the
morphine tolerant rats and we observed the change of the thermal
withdrawal latency at 15, 30, 60, 90 and 120 min after delivery of
ACPT-III.
Results: A continuous intrathecal infusion of morphine significantly
increased the thermal withdrawal latency, as compared with the
saline infused rats on day 1, with a decline on day 3 and the increase
of withdrawal latency totally disappeared on day 5 (tolerance).
Intrathecal ACPT-III increased the thermal withdrawal latency in the
morphine tolerance rats.
Conclusions: These results suggest that the group III mGluRs
may be involved in the suppression of tolerance to morphine-induced antinociception at the spinal level.

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