二陳湯(이진탕)의 네트워크 약리학 기반 다낭성난소증후군 개선 효능 연구 (Ameliorative effects of Lijin -tang on polycystic ovarian syndrome based on network pharmacology analysis)

서지정보

· 발행기관 : 대한본초학회
· 수록지 정보 : 대한본초학회지 / 40권 / 2호 / 1 ~ 11페이지
· 저자명 : 김대용, 김미혜

초록

Objectives : Polycystic ovarian syndrome (PCOS) is one of the common endocrine diseases in reproductive aged female. According to the classic Korean Medicine book, Lijin-tang could ameliorate the symptoms of PCOS. This study aimed to investigate the effects of Lijin-tang, a Korean Medicine for health insurance, on PCOS using a network pharmacology and animal experiments.
Methods : Firstly, network pharmacology analysis was conducted. The target genes of each compound consisting of Lijin-tang such were collected from PubChem database. In addition, the intersecting genes between Lijin-tang-targeted genes and PCOS-related gene set were counted, and analyzed for Functional enrichment. In letrozole-induced PCOS rats, 100, 200 and 400 mg/kg of Lijin-tang were orally administered.
Results : Network pharmacology showed that the intersecting genes between Lijin-tang and PCOS were PPARG, CYP19A, INS, IGF-1, LEP, CRP, SLC2A4, critical genes reported to relate with metabolic syndrome and insulin resistance in PCOS. FOXO1 and AMPK signaling pathway were predicted to be potential mechanisms of Lijin-tang on PCOS. Treatment of Lijin-tang recovered the estrous cycle and ameliorated the ovarian morphology such as follicular cyst and surface in letrozole-induced PCOS rats. Moreover, the number of cystic follicles was significantly decreased compared to PCOS disease rats.
Conclusions : Taken together, the results indicate that Lijin-tang could be a effective remedy for treating PCOS.

영어초록

Objectives : Polycystic ovarian syndrome (PCOS) is one of the common endocrine diseases in reproductive aged female. According to the classic Korean Medicine book, Lijin-tang could ameliorate the symptoms of PCOS. This study aimed to investigate the effects of Lijin-tang, a Korean Medicine for health insurance, on PCOS using a network pharmacology and animal experiments.
Methods : Firstly, network pharmacology analysis was conducted. The target genes of each compound consisting of Lijin-tang such were collected from PubChem database. In addition, the intersecting genes between Lijin-tang-targeted genes and PCOS-related gene set were counted, and analyzed for Functional enrichment. In letrozole-induced PCOS rats, 100, 200 and 400 mg/kg of Lijin-tang were orally administered.
Results : Network pharmacology showed that the intersecting genes between Lijin-tang and PCOS were PPARG, CYP19A, INS, IGF-1, LEP, CRP, SLC2A4, critical genes reported to relate with metabolic syndrome and insulin resistance in PCOS. FOXO1 and AMPK signaling pathway were predicted to be potential mechanisms of Lijin-tang on PCOS. Treatment of Lijin-tang recovered the estrous cycle and ameliorated the ovarian morphology such as follicular cyst and surface in letrozole-induced PCOS rats. Moreover, the number of cystic follicles was significantly decreased compared to PCOS disease rats.
Conclusions : Taken together, the results indicate that Lijin-tang could be a effective remedy for treating PCOS.

참고자료

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