근위축성측삭경화증의 전기생리학적 특징; 신경전도검사 (Electrophysiological evaluation of Amyotrophic Lateral Sclerosis; Nerve Conduction Studies)

서지정보

· 발행기관 : 한국체육과학회
· 수록지 정보 : 한국체육과학회지 / 18권 / 3호 / 1043 ~ 1051페이지
· 저자명 : 강지혁, 이윤섭

초록

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other possible causes of progressive muscle wasting. Never conduction study (NCS) is an objective, quantitative, and reproducible measure of peripheral nervous function and has been widely used for the differential diagnosis of nervous disease. METHODS: In this study we analyze the values of motor nerve conduction studies and sensory nerve conduction studies were performed; distal motor latency (DML), compound muscle action potential (CMAP), motor nerve conduction velocity (MNCV), compound nerve action potential and sensory nerve conduction velocity in 82 patients with definite ALS. RESULTS: We found slight slowing of SNCV and moderate to strong reduction of CMAP, MNCV and a prolongation of DML. We found no significant change No potential and conduction block between ALS and control. CONCLUSIONS: The main finding of the present work was moderate to strong reduction of motor nerve and slight sensory involvement in ALS. And NCS do not seem to be a sole measure to the end because they sometimes showed undistinguishable results. Accordingly, more researches on electrophysiology characteristics of NCS in ALS should be carried out for its precise clinical application in the future.

영어초록

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other possible causes of progressive muscle wasting. Never conduction study (NCS) is an objective, quantitative, and reproducible measure of peripheral nervous function and has been widely used for the differential diagnosis of nervous disease. METHODS: In this study we analyze the values of motor nerve conduction studies and sensory nerve conduction studies were performed; distal motor latency (DML), compound muscle action potential (CMAP), motor nerve conduction velocity (MNCV), compound nerve action potential and sensory nerve conduction velocity in 82 patients with definite ALS. RESULTS: We found slight slowing of SNCV and moderate to strong reduction of CMAP, MNCV and a prolongation of DML. We found no significant change No potential and conduction block between ALS and control. CONCLUSIONS: The main finding of the present work was moderate to strong reduction of motor nerve and slight sensory involvement in ALS. And NCS do not seem to be a sole measure to the end because they sometimes showed undistinguishable results. Accordingly, more researches on electrophysiology characteristics of NCS in ALS should be carried out for its precise clinical application in the future.

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