탈진적 운동부하가 염증성 장 질환 모델 흰쥐의 염증성 사이토카인 및 대장운동성에 미치는 영향 (The Effect of Exhaustion Exercise on Cytokines Related to Inflammation and Colonic Contractility in Mouse Model of Inflammatory Bowel Disease)

서지정보

· 발행기관 : 한국체육과학회
· 수록지 정보 : 한국체육과학회지 / 24권 / 5호 / 1401 ~ 1414페이지
· 저자명 : 조민호, 전윤수

초록

This experiment was conducted to define the exercise effect of inflammatory bowel disease(IBD). For this purpose we used the IL10 knock out mouse which is an experimental animal for IL10 Gene conversion trait, and categorized each control group(CON, n=7), control and exercise(CONEX, n=7), IL10 knock out (IL10KO, N=7), IL10 knock out and exercise(IL10KOEX, n=7) to excess the alteration of concentrations of inflammatory cytokine in the blood due to the exhaustible exercise. As a result, in case of the alteration of the inflammatory cytokine, IL-6, TNFα and MMP-2 showed a noticeable increase due to the exhaustible exercise compared to the CON in the gene conversion trait. This may be because the inflammatory cytokines are more reliant to the conversion of traits than the motion load. Only in case of the MMP-2's the increase in blood concentration was shown not only in the experimental animal group but also in the exhausted exercise caused by CONEX. Meanwhile, changes of contractions of bowel segment cause by chemical reaction was shown decrease in IL10KOEX regardless to the cholinergic response and nitric acid auxiliary, which is meaningless to statistics.
In conclusion, according to the result of the one-time experiment, which is the exhausted exercise conducted towards experimental animal, showed damages in intestinal mucosa's tissue and decreased the contraction of the bowel due to the increase in inflammatory cytokine. In other words, the one-time exhausted exercise have caused the escalation of the inflammatory response regarding the inflammatory bowel disease. However, it is conceivable that later it will be imperative to have an experiment that compares the high intensity exercise and the low intensity exercise. This is an experiment that is crucial for defining the effect of exercising towards inflammatory bowel disease. There are limits to this; clinical demonstration is hard due to the characteristics of the disease; it is hard to obtain experimental animal as a model. However, even though, this is a short trial regarding inflammatory bowel disease I believe it will be a rudimentary data for experiments that deals with experimental animals.

영어초록

This experiment was conducted to define the exercise effect of inflammatory bowel disease(IBD). For this purpose we used the IL10 knock out mouse which is an experimental animal for IL10 Gene conversion trait, and categorized each control group(CON, n=7), control and exercise(CONEX, n=7), IL10 knock out (IL10KO, N=7), IL10 knock out and exercise(IL10KOEX, n=7) to excess the alteration of concentrations of inflammatory cytokine in the blood due to the exhaustible exercise. As a result, in case of the alteration of the inflammatory cytokine, IL-6, TNFα and MMP-2 showed a noticeable increase due to the exhaustible exercise compared to the CON in the gene conversion trait. This may be because the inflammatory cytokines are more reliant to the conversion of traits than the motion load. Only in case of the MMP-2's the increase in blood concentration was shown not only in the experimental animal group but also in the exhausted exercise caused by CONEX. Meanwhile, changes of contractions of bowel segment cause by chemical reaction was shown decrease in IL10KOEX regardless to the cholinergic response and nitric acid auxiliary, which is meaningless to statistics.
In conclusion, according to the result of the one-time experiment, which is the exhausted exercise conducted towards experimental animal, showed damages in intestinal mucosa's tissue and decreased the contraction of the bowel due to the increase in inflammatory cytokine. In other words, the one-time exhausted exercise have caused the escalation of the inflammatory response regarding the inflammatory bowel disease. However, it is conceivable that later it will be imperative to have an experiment that compares the high intensity exercise and the low intensity exercise. This is an experiment that is crucial for defining the effect of exercising towards inflammatory bowel disease. There are limits to this; clinical demonstration is hard due to the characteristics of the disease; it is hard to obtain experimental animal as a model. However, even though, this is a short trial regarding inflammatory bowel disease I believe it will be a rudimentary data for experiments that deals with experimental animals.

참고자료

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