분할운동 훈련에 따른 흰쥐 골격근내 TNF-α, IKKα/β, NFκB의 변화 (The effect of split routine endurance training on expression of TNF-α, IKKα/β, NFκB protein in rat skeletal muscle)

서지정보

· 발행기관 : 한국체육과학회
· 수록지 정보 : 한국체육과학회지 / 21권 / 4호 / 969 ~ 977페이지
· 저자명 : 윤정수

초록

The purpose of this study is to investigate the effect of split routine and prolonged endurance training on expression of TNFα, IKKα/β, NFκB protein in rat skeletal muscle. Male SD rat(n=18) were randomly placed in one of three exercise groups(CON, split routine(SE), prolonged exercise(PE)). The rat ran the treadmill running for the intensity of 1H at VO2max 70% 5days/week during 8 weeks. The split routine endurance training composed as 30min running period and 6H of exercise interruption between each session. soleus and extensor digitorum longus muscle exercised after given exercise and western blotting analysis performed for the TNFα, IKKα/β, NFκB protein. We derived the conclusion that The expression of TNFα decreased in SE group however PE was not. IKKα/NFκB significantly increased in SE however PE decreased. This study can be concluded that split routine endurance exercise can be ameliorate inflammatory cytokine in skeletal muscle and promote the myogenic cytokines via the Ikk control signal.

영어초록

The purpose of this study is to investigate the effect of split routine and prolonged endurance training on expression of TNFα, IKKα/β, NFκB protein in rat skeletal muscle. Male SD rat(n=18) were randomly placed in one of three exercise groups(CON, split routine(SE), prolonged exercise(PE)). The rat ran the treadmill running for the intensity of 1H at VO2max 70% 5days/week during 8 weeks. The split routine endurance training composed as 30min running period and 6H of exercise interruption between each session. soleus and extensor digitorum longus muscle exercised after given exercise and western blotting analysis performed for the TNFα, IKKα/β, NFκB protein. We derived the conclusion that The expression of TNFα decreased in SE group however PE was not. IKKα/NFκB significantly increased in SE however PE decreased. This study can be concluded that split routine endurance exercise can be ameliorate inflammatory cytokine in skeletal muscle and promote the myogenic cytokines via the Ikk control signal.

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