사마귀양혈관종과 혈관각화종: 임상병리조직학적 유사점과 차이점 (Verrucous Hemangioma and Angiokeratoma: Their Similarilities and Differences according to the Clinicopathological Features)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 47권 / 4호 / 419 ~ 424페이지
· 저자명 : 정홍대, 박경덕, 지성근, 이석종, 최윤석, 김병수, 김도원, 정호윤, 윤길숙

초록

Background: Verrucous hemangioma (VH) and angiokeratoma (AK) are vascular birthmarks of an unclear nosology
and these birthmarks commonly show a superficial hyperkeratotic vascular component. There are both similarilities
and differences between VH and AK with some confusion concerning their overlapping features.
Objective: This study was undertaken to review the clinicopathological features of VHs and AKs and to determine
the similarilities and differences between them.
Methods: We retrospectively reviewed 11 VHs and 7 AKs at the Vascular Anomaly Clinic of our hospital over the
past 10 years. They were evaluated from the clinicopathologic point of view for factors such as the age of onset,
location, size, symptoms, the histopathological epithelial change and involvement of deeper tissue.
Results: These birthmarks share common clinical features with the exception of gender and lesion size.
Histopathologically, hyperkeratosis, acanthosis and capillary dilatation in the upper dermis were commonly seen. Yet
lobular proliferation and dilatation of blood vessels in the deep dermis, or more importantly, the subcutis were
detected in VH only. Furthermore there was a case of VH that showed diffusely scattered increased blood vessels
in the subcutis, suggesting an evolving stage of VH and there was another case of VH that was erroneously
diagnosed as AK via the initial biopsy, and the final diagnosis was changed according to the excised lesion.
Conclusion: The two diseases share most of their clinicopathological features, but small parts of features like gender,
the clinical size and the histological deep dermis/subcutis involvement were differences. Making the correct differential
diagnosis between VH and AK through a deep biopsy with appropriate timing and long-term follow-up and/or
radiological examination is helpful to avoid erroneous management.

영어초록

Background: Verrucous hemangioma (VH) and angiokeratoma (AK) are vascular birthmarks of an unclear nosology
and these birthmarks commonly show a superficial hyperkeratotic vascular component. There are both similarilities
and differences between VH and AK with some confusion concerning their overlapping features.
Objective: This study was undertaken to review the clinicopathological features of VHs and AKs and to determine
the similarilities and differences between them.
Methods: We retrospectively reviewed 11 VHs and 7 AKs at the Vascular Anomaly Clinic of our hospital over the
past 10 years. They were evaluated from the clinicopathologic point of view for factors such as the age of onset,
location, size, symptoms, the histopathological epithelial change and involvement of deeper tissue.
Results: These birthmarks share common clinical features with the exception of gender and lesion size.
Histopathologically, hyperkeratosis, acanthosis and capillary dilatation in the upper dermis were commonly seen. Yet
lobular proliferation and dilatation of blood vessels in the deep dermis, or more importantly, the subcutis were
detected in VH only. Furthermore there was a case of VH that showed diffusely scattered increased blood vessels
in the subcutis, suggesting an evolving stage of VH and there was another case of VH that was erroneously
diagnosed as AK via the initial biopsy, and the final diagnosis was changed according to the excised lesion.
Conclusion: The two diseases share most of their clinicopathological features, but small parts of features like gender,
the clinical size and the histological deep dermis/subcutis involvement were differences. Making the correct differential
diagnosis between VH and AK through a deep biopsy with appropriate timing and long-term follow-up and/or
radiological examination is helpful to avoid erroneous management.

참고자료

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